Assessment of brain core temperature using MR DWI-thermometry in Alzheimer disease patients compared to healthy subjects

• Published in: Japanese journal of radiology Vol. 35; no. 4; pp. 168 - 171
• Main Authors: Sparacia, Gianvincenzo, Sakai, Koji, Yamada, Kei, Giordano, Giovanna, Coppola, Rosalia, Midiri, Massimo, Grimaldi, Luigi Maria
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.04.2017; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Body Temperature; Brain - diagnostic imaging; Brain - metabolism; Brain - physiopathology; Case-Control Studies; Diffusion Magnetic Resonance Imaging - methods; Female; Humans; Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Nuclear Medicine; Original Article; Radiology; Radiotherapy; Retrospective Studies; Thermometry - methods; Diffusion-weighted imaging; Brain; Diffusion-weighted imaging temperature; MRI; Alzheimer disease
• ISSN: 1867-1071; 1867-108X; 1867-108X
• DOI: 10.1007/s11604-017-0616-0

Purpose To assess the brain core temperature of Alzheimer disease (AD) patients in comparison with healthy volunteers using diffusion-weighted thermometry. Materials and methods Fourteen AD patients (3 men, 11 women; age range 60–81 years, mean age 73.8 ± 6.1 years) and 14 healthy volunteers, age and sex-matched (mean age 70.1 ± 6.9 years; range 62–84 years; 5 men, 9 women) underwent MR examination between February 2014 and March 2016. MR imaging studies were performed with a 1.5-T MR scanner. Brain core temperature ( T : °C) was calculated using the following equation from the diffusion coefficient ( D ) in the lateral ventricular (LV) cerebrospinal fluid: T  = 2256.74/ln (4.39221/ D ) − 273.15 using a standard DWI single-shot echo-planar pulse sequence ( b value 1000 s/mm 2 ). Statistical analysis was performed using a nonparametric Wilcoxon rank-sum test to compare the patient and control groups regarding LV temperatures. Results There was no significant difference ( P  = 0.1937) in LV temperature between patients (mean 37.9 ± 1.1 °C, range 35.8–39.2 °C) and control group (38.7 ± 1.4 °C, range 36.9–42.7 °C). Conclusions Brain core temperature in AD patients showed no significant alterations compared to healthy volunteers.