Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure

Despite improvements in modern cardiovascular therapy, the morbidity and mortality of ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and worldwide. Patients with IHD may benefit from therapies that would accelerate natural processes of postnatal collateral vessel f...

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Published inEuropean heart journal Vol. 37; no. 23; pp. 1789 - 1798
Main Authors Madonna, Rosalinda, Van Laake, Linda W, Davidson, Sean M, Engel, Felix B, Hausenloy, Derek J, Lecour, Sandrine, Leor, Jonathan, Perrino, Cinzia, Schulz, Rainer, Ytrehus, Kirsti, Landmesser, Ulf, Mummery, Christine L, Janssens, Stefan, Willerson, James, Eschenhagen, Thomas, Ferdinandy, Péter, Sluijter, Joost P G
Format Journal Article
LanguageEnglish
Published England Oxford University Press 14.06.2016
Subjects
Cell Tracking - methods
Cell- and Tissue-Based Therapy - methods
Clinical Trials as Topic
Current Opinion
Data Accuracy
Ethics, Medical
Heart - physiology
Heart Failure - physiopathology
Heart Failure - therapy
Humans
Myocardial Ischemia - physiopathology
Myocardial Ischemia - therapy
Patient Safety
Patient Selection
Regeneration - physiology
Stem Cell Transplantation - methods
Stroke Volume - physiology
Treatment Outcome
Heart Failure
Cell-based therapy
Ischaemic heart disease
Heart Regeneration
Heart repair
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Summary:Despite improvements in modern cardiovascular therapy, the morbidity and mortality of ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and worldwide. Patients with IHD may benefit from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Here, we discuss the use of cells in the context of heart repair, and the most relevant results and current limitations from clinical trials using cell-based therapies to treat IHD and HF. We identify and discuss promising potential new therapeutic strategies that include ex vivo cell-mediated gene therapy, the use of biomaterials and cell-free therapies aimed at increasing the success rates of therapy for IHD and HF. The overall aim of this Position Paper of the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to improve the therapeutic application of cell-based therapies for cardiac regeneration and repair.
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These authors contributed equally.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehw113