Field randomized trial to evaluate the efficacy of the Leish-Tec® vaccine against canine visceral leishmaniasis in an endemic area of Brazil

• Published in: Vaccine Vol. 34; no. 19; pp. 2233 - 2239
• Main Authors: Regina-Silva, Shara, Feres, Ana Maria Leonardi Tibúrcio, França-Silva, João Carlos, Dias, Edelberto Santos, Michalsky, Érika Monteiro, de Andrade, Hélida Monteiro, Coelho, Eduardo Antonio Ferraz, Ribeiro, Gustavo Meirelles, Fernandes, Ana Paula, Machado-Coelho, George Luiz Lins
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 27.04.2016; Elsevier Limited
• Subjects: A2 antigen; Allergy and Immunology; Animal euthanasia; Animals; Antibodies, Protozoan - blood; Antigens, Protozoan - immunology; Brazil; Canine visceral leishmaniasis; Dog Diseases - parasitology; Dog Diseases - prevention & control; Dogs; Efficacy; Immunity, Humoral; Immunology; Infections; Leish-Tec; Leishmaniasis Vaccines - therapeutic use; Leishmaniasis, Visceral - prevention & control; Leishmaniasis, Visceral - veterinary; Mortality; Parasites; Parasitic diseases; Proteins; Protozoan Proteins - immunology; Psychodidae - parasitology; Randomized field trial; Rural areas; Vaccine; Vaccines; Xenodiagnosis; Zoonoses; Brazil; Leish-Tec; A2 antigen; Efficacy; Vaccine; Randomized field trial; Canine visceral leishmaniasis; Leish-Tec(®)
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2016.03.019

Highlights • Randomized field trial (RTF) to demonstrate Leish-Tec® vaccine efficacy against canine visceral leishmaniasis. • A high transmission pressure and parasite challenge was assured for demonstrating vaccine efficacy. • Leish-Tec® vaccination was significant effective (71%) for prophylaxis of CVL. • Efficacy was higher among animals presenting with increased levels of anti-A2 antibodies (81%). • A tendency to reduced transmission of parasites to sand fly vectors was also observed among vaccinated animals.