Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner

• Published in: Neurobiology of aging Vol. 36; no. 4; pp. 1619 - 1628
• Main Authors: Gietl, Anton F, Warnock, Geoffrey, Riese, Florian, Kälin, Andrea M, Saake, Antje, Gruber, Esmeralda, Leh, Sandra E, Unschuld, Paul G, Kuhn, Felix P, Burger, Cyrill, Mu, Linjing, Seifert, Burkhardt, Nitsch, Roger M, Schibli, Roger, Ametamey, Simon M, Buck, Alfred, Hock, Christoph
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015
• Subjects: Aged; Aged, 80 and over; Aging; Aging - metabolism; Aging - pathology; Aging - physiology; Alleles; Alzheimer's disease; Amyloid; Amyloidogenic Proteins - metabolism; Aniline Compounds - metabolism; Apolipoprotein E4 - genetics; Biomarker; Brain - blood supply; Brain - metabolism; Cerebral blood flow; Cognition; Cognitive Dysfunction - genetics; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - physiopathology; Cognitive Dysfunction - psychology; Female; Frontal; Genotype; Hippocampus; Humans; Internal Medicine; Male; MCI; Middle Aged; MRI; Neurology; PET; PiB; Posterior cingulate cortex; Regional Blood Flow; Thiazoles - metabolism; Biomarker; MCI; Cerebral blood flow; MRI; PiB; Frontal; Aging; Amyloid; Alzheimer's disease; PET; Hippocampus; Posterior cingulate cortex
• ISSN: 0197-4580; 1558-1497
• DOI: 10.1016/j.neurobiolaging.2014.12.036

Abstract Early uptake of [11 C]-Pittsburgh Compound B (ePiB, 0–6 minutes) estimates cerebral blood flow. We studied ePiB in 13 PiB-negative and 10 PiB-positive subjects with mild cognitive impairment (MCI, n  = 23) and 11 PiB-positive and 74 PiB-negative cognitively healthy elderly control subjects (HCS, n  = 85) in 6 bilateral volumes of interest: posterior cingulate cortex (PCC), hippocampus (hipp), temporoparietal region, superior parietal gyrus, parahippocampal gyrus (parahipp), and inferior frontal gyrus (IFG) for the associations with cognitive status, age, amyloid deposition, and apolipoprotein E ε4-allele. We observed no difference in ePiB between PiB-positive and -negative subjects and carriers and noncarriers. EPiB decreased with age in PiB-positive subjects in bilateral superior parietal gyrus, bilateral temporoparietal region, right IFG, right PCC, and left parahippocampal gyrus but not in PiB-negative subjects. MCI had lower ePiB than HCS (left PCC, left IFG, and left and right hipp). Lowest ePiB values were found in MCI of 70 years and older, who also displayed high cortical PiB binding. This suggests that lowered regional cerebral blood flow indicated by ePiB is associated with age in the presence but not in the absence of amyloid pathology.