Advancing the global public health agenda for NAFLD: a consensus statement

• Published in: Nature reviews. Gastroenterology & hepatology Vol. 19; no. 1; pp. 60 - 78
• Main Authors: Lazarus, Jeffrey V., Arab, Juan Pablo, Castera, Laurent, Cortez-Pinto, Helena, Cusi, Kenneth, Francque, Sven, Hunyady, Bela, Kalamitsis, George, Kao, Jia-Horng, Kaplan, Lee, Kawaguchi, Takumi, Khader, Yousef, Kim, Seung Up, Kodjoh, Nicolas, Koek, Ger, Komas, Narcisse Patrice, Kugelmas, Marcelo, Labidi, Asma, Lavine, Joel E., Lazo, Mariana, Huang, Terry T.-K., Long, Michelle T., Marchesini, Giulio, Nlombi, Charles Mbendi, Milovanovic, Tamara, Musso, Carla, Nakajima, Atsushi, Nava, Edna, Nikolova, Dafina, Norris, Suzanne, Novak, Katja, Kautz, Achim, Papatheodoridis, George, Patel, Keyur, Figueroa, Marlene Pérez, Puri, Puneet, Pan, Calvin Q., Rac, Marek, Alvares-da-Silva, Mario Reis, Roberts, Stuart, Roden, Michael, Rouabhia, Samir, Salupere, Riina, Seki, Yosuke, Serme, Abdel Karim, Shaw, Jonathan E., Shenoy, Thrivikrama, Silva, Marcelo, Skrypnyk, Igor, Socha, Piotr, Newsome, Philip N., Spearman, C. Wendy, Sridharan, Kannan, Sung, Ki-Chul, Swain, Mark, Tan, Soek-Siam, Thiele, Maja, Tolmane, Ieva, Treeprasertsuk, Sombat, Ocama, Ponsiano, Vesterhus, Mette, Wild, Sarah H., Xanthakos, Stavra, Zheng, Kenneth I., Zeybel, Mudjat, Ratziu, Vlad, Zheng, Ming-Hua, Rinella, Mary, Romero, Diana, Adams, Leon, Murillo, Omar Alfaro, Alswat, Khalid, Arrese, Marco, Awuku, Yaw Asante, Baatarkhuu, Oidov, Bakieva, Shokhista, Basu, Rita, Bedri, Shahinaz, Bourliere, Marc, Bugianesi, Elisabetta, Buti, Maria, Byrne, Christopher D., Carrieri, Patrizia, Corey, Kathleen, Craxi, Antonio, Cryer, Donna, Dassanayake, Anuradha, Martins, Antonieta de Ascenção Soares, de Ledinghen, Victor, Dillon, John, Duseja, Ajay, Esmat, Gamal, Fan, Jian-Gao, Farpour-Lambert, Nathalie, Flisiak, Robert, Fuchs, Michael, Gani, Rino A., Ghazinyan, Hasmik, Grønbæk, Henning, Gulnara, Aghayeva
• Format: Journal Article
• Language: English
• Published: London Springer Nature 01.01.2022; Nature Publishing Group UK; Nature Publishing Group
• Subjects: 692/4020/1503/1607/2750; 692/700/228; 692/700/478; Biomedicine; Consensus Statement; Epidemiology; Fatty liver; Gastroenterology; Hepatology; Humans; Liver diseases; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Metabolic syndrome; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - epidemiology; Non-alcoholic Fatty Liver Disease - therapy; Public health
• ISSN: 1759-5045; 1759-5053; 1759-5053
• DOI: 10.1038/s41575-021-00523-4

© Springer Nature Limited 2021, corrected publication 2021 Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics - from epidemiology, awareness, care and treatment to public health policies and leadership - that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD.