The effect of low lung volume on airway function in obesity

• Published in: Respiratory physiology & neurobiology Vol. 188; no. 2; pp. 192 - 199
• Main Authors: Mahadev, Sriram, Salome, Cheryl M., Berend, Norbert, King, Gregory G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2013
• Subjects: Adolescent; Adult; Aged; Airway closure; Airway Resistance - physiology; Female; Forced oscillation technique; Humans; Lung - physiopathology; Male; Medical Education; Middle Aged; Nitrogen - administration & dosage; Obesity; Obesity - pathology; Obesity - physiopathology; Pulmonary/Respiratory; Respiration; Spirometry; Ventilation distribution; Vital Capacity; Young Adult; Airway closure; Obesity; Forced oscillation technique; Ventilation distribution
• ISSN: 1569-9048; 1878-1519; 1878-1519
• DOI: 10.1016/j.resp.2013.05.021

•Obesity is associated with reduced operating lung volume.•Breathing at low operating lung volume leads to airway closure during tidal breathing.•Airway closure does not begin earlier in exhalation in the obese.•Low lung volume and tidal airway closure affects airway function.•After accounting for lung volume, abnormalities in ventilation heterogeneity in very peripheral airways and in airway caliber persist. Obesity is associated with reduced operating lung volume. We hypothesized that obesity induces airway dysfunction independent of reduced FRC. 18 obese (BMI: 41.3±6.8) and 17 non-obese subjects (BMI: 24.8±2.3kg/m2) had measurements of conductance (Grs) and reactance (Xrs) by forced oscillation technique, ventilation heterogeneity (lung clearance index (LCI), Scond, Sacin) by multiple breath nitrogen washout and closing capacity (CC) by single breath nitrogen washout. Obese had higher LCI and Sacin and lower Grs and Xrs. After adjustment for FRC, Grs (r=−0.52, p=0.001), and Sacin (r=0.47, p=0.004) still correlated with BMI. Closing capacity (as % predicted TLC) was not increased but was closer to FRC in the obese (CC/FRC: 95.0±21.7% vs 71.7±19.2%, p<0.001). Xrs and LCI correlated with CC/FRC. In obesity, there are abnormalities in airway function that are independent of reduced FRC. Airway closure is not increased but CC occurs close to FRC, affecting Xrs and LCI.