The management of chronic hepatitis C: 2018 guideline update from the Canadian Association for the Study of the Liver

Chronic hepatitis C virus (HCV) is a highly burdensome public health problem in Canada, causing more years of life lost than any other infectious disease in the country. A recent modelling study suggested that about 252 000 Canadians (uncertainty interval: 178 000-315 000 Canadians) were chronically...

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Published inCanadian Medical Association journal (CMAJ) Vol. 190; no. 22; pp. E677 - E687
Main Authors Shah, Hemant, MD MScCH(HPTE), Feld, Jordan J., MD MPH, Bilodeau, Marc, MD, Burak, Kelly W., MD MSc, Cooper, Curtis, MD, Klein, Marina, MD MSc, Ramji, Alnoor, MD, Smyth, Dan, MD
Format Journal Article
LanguageEnglish
Published Canada Joule Inc 04.06.2018
CMA Impact, Inc
Subjects
Canadians
Chronic illnesses
Communicable diseases
Drug therapy
Epidemiology
Genotype & phenotype
Guideline
Guidelines
Health aspects
Health care
Hepatitis
Hepatitis C
Hepatitis C virus
Hepatology
Infection
Infections
Infectious diseases
Interferon
Internal Medicine
Kidney diseases
Liver cancer
Medical research
Mortality
Officials and employees
Patients
Pharmaceutical industry
Public health
Therapy
Viral infections
Viruses
Canada
United States
Ontario Canada
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Summary:Chronic hepatitis C virus (HCV) is a highly burdensome public health problem in Canada, causing more years of life lost than any other infectious disease in the country. A recent modelling study suggested that about 252 000 Canadians (uncertainty interval: 178 000-315 000 Canadians) were chronically infected in 2013. The birth cohort of 1945-1975 has the highest prevalence of chronic HCV infection, yet it is estimated that up to 70% of this group have not been tested for HCV. The primary objective of anti-HCV therapy is complete eradication of the virus, termed a sustained virologic response, which is defined as absence of viremia 12 weeks after completion of therapy. 5 Once achieved, sustained virologic response is considered a true cure of the viral infection, as late relapses are very uncommon. The landscape for HCV treatment continues to change at a rapid pace. This guideline provides updated evidence-based recommendations for the treatment of patients with HCV infection.
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ISSN:0820-3946
1488-2329
DOI:10.1503/cmaj.170453