Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions

We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions. The present protocol for preparation of biologically important 4-oxo-tetrahydroindoles offers several advantages such as mild reaction conditions, improved selectivity an...

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Bibliographic Details
Published inRSC advances Vol. 9; no. 68; pp. 39735 - 39742
Main Authors Lambat, Trimurti L, Abdala, Ahmed A, Mahmood, Sami, Ledade, Pankaj V, Chaudhary, Ratiram G, Banerjee, Subhash
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 03.12.2019
The Royal Society of Chemistry
Subjects
Ball milling
Chemical synthesis
Chemistry
Selectivity
Sulfamic acid
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Summary:We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions. The present protocol for preparation of biologically important 4-oxo-tetrahydroindoles offers several advantages such as mild reaction conditions, improved selectivity and higher isolated yields. Moreover, solvent-free reaction conditions and the use of ball milling make the present protocol environmentally friendly in nature. We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions.
Bibliography:10.1039/c9ra08478a
Electronic supplementary information (ESI) available. See DOI
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SourceType-Scholarly Journals-1
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ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra08478a