Disentangling the percepts of illusory movement and sensory stimulation during tendon vibration in the EEG

• Published in: NeuroImage (Orlando, Fla.) Vol. 241; p. 118431
• Main Authors: Schneider, Christoph, Marquis, Renaud, Jöhr, Jane, Lopes da Silva, Marina, Ryvlin, Philippe, Serino, Andrea, De Lucia, Marzia, Diserens, Karin
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.11.2021; Elsevier Limited; Elsevier
• Subjects: Classification; Clinical trials; Cognitive ability; EEG; Elbow; Electroencephalography; Event-related De/Synchronization (ERD/ERS); Event-related potentials; Experiments; Functional proprioceptive stimulation (FPS); Movement/Kinesthetic illusion; Neuroimaging; Perception; Perceptions; Proprioception; Synchronization; Tendon co-vibration; Tendons; Vibration; Movement/Kinesthetic illusion; Tendon co-vibration; Event-related De/Synchronization (ERD/ERS); Event-related potentials; Functional proprioceptive stimulation (FPS); Classification
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2021.118431

Mechanical vibration of muscle tendons in specific frequencies – termed functional proprioceptive stimulation (FPS) – has the ability to induce the illusion of a movement which is congruent with a lengthening of the vibrated tendon and muscle. The majority of previous reports of the brain correlates of this illusion are based on functional neuroimaging. Contrary to the electroencephalogram (EEG) however, such technologies are not suitable for bedside or ambulant use. While a handful of studies have shown EEG changes during FPS, it remains underinvestigated whether these changes were due to the perceived illusion or the perceived vibration. Here, we aimed at disentangling the neural correlates of the illusory movement from those produced by the vibration sensation by comparing the neural responses to two vibration types, one that did and one that did not elicit an illusion. We recruited 40 naïve participants, 20 for the EEG experiment and 20 for a supporting behavioral study, who received functional tendon co-vibration on the biceps and triceps tendon at their left elbow, pseudo-randomly switching between the illusion and non-illusion trials. Time-frequency decomposition uncovered a strong and lasting event-related desynchronization (ERD) in the mu and beta band in both conditions, suggesting a strong somatosensory response to the vibration. Additionally, the analysis of the evoked potentials revealed a significant difference between the two experimental conditions from 310 to 990ms post stimulus onset. Training classifiers on the frequency-based and voltage-based correlates of illusion perception yielded above chance accuracies for 17 and 13 out of the 20 subjects respectively. Our findings show that FPS-induced illusions produce EEG correlates that are distinct from a vibration-based control and which can be classified reliably in a large number of participants. These results encourage pursuing EEG-based detection of kinesthetic illusions as a tool for clinical use, e.g., to uncover aspects of cognitive perception in unresponsive patients.