SPINE high-throughput crystallization, crystal imaging and recognition techniques: current state, performance analysis, new technologies and future aspects

This paper reviews the developments in high‐throughput and nanolitre‐scale protein crystallography technologies within the remit of workpackage 4 of the Structural Proteomics In Europe (SPINE) project since the project's inception in October 2002. By surveying the uptake, use and experience of...

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Published inActa crystallographica. Section D, Biological crystallography. Vol. 62; no. 10; pp. 1137 - 1149
Main Authors Berry, Ian M., Dym, O., Esnouf, R. M., Harlos, K., Meged, R., Perrakis, A., Sussman, J. L., Walter, T. S., Wilson, J., Messerschmidt, Albrecht
Format Journal Article
LanguageEnglish
Published 5 Abbey Square, Chester, Cheshire CH1 2HU, England Blackwell Publishing Ltd 01.10.2006
Subjects
automation
crystallization
Crystallography - instrumentation
Crystallography - methods
Crystallography - trends
Image Processing, Computer-Assisted
minimization
Nanotechnology
Plastics
Proteins - chemistry
Proteomics
Quality Control
Robotics
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Summary:This paper reviews the developments in high‐throughput and nanolitre‐scale protein crystallography technologies within the remit of workpackage 4 of the Structural Proteomics In Europe (SPINE) project since the project's inception in October 2002. By surveying the uptake, use and experience of new technologies by SPINE partners across Europe, a picture emerges of highly successful adoption of novel working methods revolutionizing this area of structural biology. Finally, a forward view is taken of how crystallization methodologies may develop in the future.
Bibliography:ark:/67375/WNG-VW5L5CBC-J
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ArticleID:AYDGX5086
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1399-0047
0907-4449
1399-0047
DOI:10.1107/S090744490602943X