Oxidation of Linoleic Acid in Low-Density Lipoprotein: An Important Event in Atherogenesis

• Published in: Angewandte Chemie (International ed.) Vol. 39; no. 3; pp. 585 - 589
• Main Authors: Spiteller, Dieter, Spiteller, Gerhard
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag GmbH 04.02.2000; WILEY‐VCH Verlag GmbH
• Subjects: atherosclerosis; fatty acids; lipids; lipoproteins; oxygenations

Contrary to earlier views the main oxidation products of low‐density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as...