Oxidation of Linoleic Acid in Low-Density Lipoprotein: An Important Event in Atherogenesis

Contrary to earlier views the main oxidation products of low‐density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as...

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Published inAngewandte Chemie (International ed.) Vol. 39; no. 3; pp. 585 - 589
Main Authors Spiteller, Dieter, Spiteller, Gerhard
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 04.02.2000
WILEY‐VCH Verlag GmbH
Subjects
atherosclerosis
fatty acids
lipids
lipoproteins
oxygenations
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Summary:Contrary to earlier views the main oxidation products of low‐density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as 1 and 2 have been identified for the first time, is obtained from minimally oxidized (that is, aged) LDL. Since this is still recognized by the LDL receptor, it is concluded that toxic oxidation products are introduced in endothelial cells in vivo and cause damage there.
Bibliography:ArticleID:ANIE585
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istex:41125C74260F22DA70B77406B38848B8DAD35F22
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-G