Oxidation of Linoleic Acid in Low-Density Lipoprotein: An Important Event in Atherogenesis
Contrary to earlier views the main oxidation products of low‐density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as...
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Published in | Angewandte Chemie (International ed.) Vol. 39; no. 3; pp. 585 - 589 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag GmbH
04.02.2000
WILEY‐VCH Verlag GmbH |
Subjects | |
Online Access | Get full text |
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Summary: | Contrary to earlier views the main oxidation products of low‐density lipoprotein (LDL) are derived from linoleic acid and not arachidonic acid, as determined by GC/MS investigations of the in vitro oxidation of LDL samples. A similar product spectrum, in which epoxyhydroxyoctadecenoic acids such as 1 and 2 have been identified for the first time, is obtained from minimally oxidized (that is, aged) LDL. Since this is still recognized by the LDL receptor, it is concluded that toxic oxidation products are introduced in endothelial cells in vivo and cause damage there. |
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Bibliography: | ArticleID:ANIE585 ark:/67375/WNG-ZXB2TCLJ-J istex:41125C74260F22DA70B77406B38848B8DAD35F22 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/(SICI)1521-3773(20000204)39:3<585::AID-ANIE585>3.0.CO;2-G |