Quantitative evaluation of radiation-induced lung injury with hyperpolarized xenon magnetic resonance
Purpose To demonstrate the feasibility of quantitative and comprehensive global evaluation of pulmonary function and microstructural changes in rats with radiation‐induced lung injury (RILI) using hyperpolarized xenon MR. Methods Dissolved xenon spectra were dynamically acquired using a modified che...
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Published in | Magnetic resonance in medicine Vol. 76; no. 2; pp. 408 - 416 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.08.2016
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose
To demonstrate the feasibility of quantitative and comprehensive global evaluation of pulmonary function and microstructural changes in rats with radiation‐induced lung injury (RILI) using hyperpolarized xenon MR.
Methods
Dissolved xenon spectra were dynamically acquired using a modified chemical shift saturation recovery pulse sequence in five rats with RILI (bilaterally exposed by 6‐MV x‐ray with a dose of 14 Gy 3 mo. prior to MR experiments) and five healthy rats. The dissolved xenon signals were quantitatively analyzed, and the pulmonary physiological parameters were extracted with the model of xenon exchange.
Results
The obtained pulmonary physiological parameters and the ratio of 129Xe signal in red blood cells (RBCs) versus barrier showed a significant difference between the groups. In RILI rats versus controls, the exchange time increased from 44.5 to 112 ms, the pulmonary capillary transit time increased from 0.51 to 1.48 s, and the ratio of 129Xe spectroscopic signal in RBCs versus barrier increased from 0.294 to 0.484.
Conclusion
Hyperpolarized xenon MR is effective for quantitative and comprehensive global evaluation of pulmonary function and structural changes without the use of radiation. This may open the door for its use in the diagnosis of lung diseases that are related to gas exchange. Magn Reson Med 76:408–416, 2016. © 2015 Wiley Periodicals, Inc. |
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Bibliography: | istex:22BA9699187CF44E521DAF74B729A1DF4E369811 ark:/67375/WNG-QPTQLBS1-3 ArticleID:MRM25894 Natural Science Foundation of China - No. 81227902; No. 11174327 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0740-3194 1522-2594 |
DOI: | 10.1002/mrm.25894 |