Self-assembling peptides as injectable lubricants for osteoarthritis
The self‐assembly of peptides is explored as an alternative route towards the development of new injectable joint lubricants for osteoarthritis (OA). The versatility of the peptide chemistry allows the incorporation of behavior reminiscent of hyaluronic acid (HA), while the triggered in situ self‐as...
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Published in | Journal of biomedical materials research. Part A Vol. 78A; no. 2; pp. 236 - 246 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.08.2006
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Subjects | |
Online Access | Get full text |
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Summary: | The self‐assembly of peptides is explored as an alternative route towards the development of new injectable joint lubricants for osteoarthritis (OA). The versatility of the peptide chemistry allows the incorporation of behavior reminiscent of hyaluronic acid (HA), while the triggered in situ self‐assembly provides easy delivery of the samples by injection due to the low viscosity of the peptide solutions (that are initially monomeric). Using design criteria based on the chemical properties of HA, a range of de novo peptides were prepared with systematic alterations of charge and hydrophilicity that self‐assembled into nematic fluids and gels in physiological solution conditions. The frictional characteristics of the peptides were evaluated using cartilage on cartilage sliding contacts along with their rheological characteristics. Peptide P11‐9, whose molecular, mesoscopic, and rheological properties most closely resembled HA was found to be the most effective lubricant amongst the peptides. In healthy static and dynamic friction testing (corresponding to healthy joints) P11‐9 at 20–40 mg/mL performed similar to HA at 10 mg/mL. In friction tests with damaged cartilage (corresponding to early stage OA) P11‐9 was a less efficient lubricant than HA, but still the best among all the peptides tested. The results indicate that de novo self‐assembling peptides could be developed as an alternate therapeutic lubricant for early stage OA. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006 |
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Bibliography: | istex:A7D96F751F666225F3E5D9CF71611279413EDD24 Royal Society ark:/67375/WNG-HNQ9GT00-3 ORSAS (Overseas Research Students Awards Scheme) ArticleID:JBM30672 Engineering and Physical Sciences Research Council ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1549-3296 1552-4965 |
DOI: | 10.1002/jbm.a.30672 |