GABAA receptor-acting neurosteroids: A role in the development and regulation of the stress response

Highlights • GABAA receptors (GABAA Rs) curtail stress-induced activation of the HPA axis. • Stressful challenges evoke de novo brain synthesis of GABAA R-active neurosteroids (NS). • NS inhibit the output of CRF-releasing neurones of the hypothalamus. • NS actions in the hypothalamus are blunted in...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neuroendocrinology Vol. 36; pp. 28 - 48
Main Authors Gunn, Benjamin G, Cunningham, Linda, Mitchell, Scott G, Swinny, Jerome D, Lambert, Jeremy J, Belelli, Delia
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2015
Academic Press
Subjects
Allopregnanolone
Depression
Early-life stress
Endocrinology & Metabolism
GABAA receptor
HPA axis
Humans
Hypothalamo-Hypophyseal System - metabolism
Neurotransmitter Agents - metabolism
Pituitary-Adrenal System - metabolism
Receptors, GABA-A - metabolism
Review
Stress, Psychological - metabolism
Early-life stress
Depression
HPA axis
GABA A receptor
Allopregnanolone
GABAA receptor
GABA(A) receptor
Online AccessGet full text

Cover

More Information
Summary:Highlights • GABAA receptors (GABAA Rs) curtail stress-induced activation of the HPA axis. • Stressful challenges evoke de novo brain synthesis of GABAA R-active neurosteroids (NS). • NS inhibit the output of CRF-releasing neurones of the hypothalamus. • NS actions in the hypothalamus are blunted in rodent models of early-life adversity. • NS may be important molecular messengers in the programming of the stress-response.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0091-3022
1095-6808
DOI:10.1016/j.yfrne.2014.06.001