A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing

• Published in: Translational psychiatry Vol. 15; no. 1; pp. 196 - 10
• Main Authors: Klöbl, Manfred, Murgaš, Matej, Reed, Murray Bruce, Silberbauer, Leo Robert, Hartmann, Annette M., Godbersen, Godber Mathis, Gryglewski, Gregor, Nics, Lukas, Hahn, Andreas, Rujescu, Dan, Hacker, Marcus, Lanzenberger, Rupert
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.06.2025; Nature Publishing Group
• Subjects: 59/36; 59/78; 631/378/340; 692/699/476/1414; Adult; Behavioral Sciences; Biological Psychology; Citalopram - pharmacology; Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - genetics; Depressive Disorder, Major - metabolism; Depressive Disorder, Major - physiopathology; Depressive Disorder, Major - psychology; Emotions; Emotions - drug effects; Emotions - physiology; Facial Expression; Facial Recognition - drug effects; Facial Recognition - physiology; Female; Gyrus Cinguli - diagnostic imaging; Gyrus Cinguli - drug effects; Gyrus Cinguli - physiopathology; Humans; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Mental depression; Middle Aged; Neurosciences; Pharmacotherapy; Positron-Emission Tomography; Psychiatry; Selective Serotonin Reuptake Inhibitors - pharmacology; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins - genetics; Serotonin Plasma Membrane Transport Proteins - metabolism; Tranquilizers; Young Adult

Considering the complexity of serotonergic influence on emotions, we conducted a comprehensive investigation of the interplay between emotion processing and the serotonergic system using simultaneous functional and molecular neuroimaging during pharmacological challenge while disentangling the effec...