Surveillance of Duodenal Adenomas in Familial Adenomatous Polyposis Reveals High Cumulative Risk of Advanced Disease

• Published in: Journal of clinical oncology Vol. 22; no. 3; pp. 493 - 498
• Main Authors: SAURIN, Jean-Christophe, GUTKNECHT, Christelle, NAPOLEON, Bertrand, CHAVAILLON, An Nick, ECOCHARD, René, SCOAZEC, Jean-Yves, PONCHON, Thierry, CHAYVIALLE, Jean-Alain
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 01.02.2004; Lippincott Williams & Wilkins
• Subjects: Adenoma - diagnosis; Adenoma - physiopathology; Adenoma - surgery; Adenomatous Polyposis Coli - diagnosis; Adenomatous Polyposis Coli - physiopathology; Adult; Biological and medical sciences; Disease Progression; Duodenal Neoplasms - diagnosis; Duodenal Neoplasms - physiopathology; Duodenal Neoplasms - surgery; Duodenoscopy; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Life Sciences; Male; Medical sciences; Middle Aged; Neoplasm Staging; Other; Prognosis; Prospective Studies; Risk Factors; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; High risk; Duodenum; Digestive system; Adenoma; Familial adenomatous polyposis coli; Small intestine; Genetic disease; Cancerology; Surveillance; Digestive diseases; Intestinal disease; Advanced stage; Benign neoplasm
• ISSN: 0732-183X; 1527-7755
• DOI: 10.1200/JCO.2004.06.028

The development of high-grade dysplasia (HGD) on duodenal or jejunal adenomas and of late-stage (stage IV) duodenal polyposis are major clinical events for familial adenomatous polyposis (FAP) patients. Our aim was to determine their respective frequency, risk factors, and cumulative risk. A prospective, optimized, endoscopic surveillance protocol was applied to 58 FAP patients in a university hospital. The number, size, and histology of duodenojejunal polyps were assessed, and the Spigelman's score was calculated at each endoscopy. Cox regression and linear regression analysis were used to determine risk factors for HGD development and the cumulative risk of stage IV duodenal polyposis, respectively. During a median (+/- standard deviation) follow-up of 47.9 +/- 15.6 months, 35 patients with at least two consecutive examinations had 107 duodenojejunal examinations. The Spigelman's score increased in 21 patients (60.0%), and HGD developed in 12 patients (34.2%). High initial Spigelman's score (> 7 points), but not age or APC mutation site, was a risk factor for HGD development. Estimated cumulative risk of developing stage IV duodenal polyposis was of 42.9% at age 60 (95% CI, 35.7% to 50.0%) and 50.0% at age 70 (95% CI, 42.9% to 57.1%). This prospective series shows a higher duodenal polyposis progression rate and cumulative risk of late-stage (stage IV) duodenal polyposis in FAP patients compared with previous series. These results suggest that current modalities for surveillance and management of these patients need revision.