The redox requirements of proliferating mammalian cells

Cell growth and division require nutrients, and proliferating cells use a variety of sources to acquire the amino acids, lipids, and nucleotides that support macromolecule synthesis. Lipids are more reduced than other nutrients, whereas nucleotides and amino acids are typically more oxidized. Cells...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 293; no. 20; pp. 7490 - 7498
Main Authors Hosios, Aaron M., Vander Heiden, Matthew G.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 18.05.2018
American Society for Biochemistry and Molecular Biology
Subjects
Animals
cell metabolism
Cell Physiological Phenomena
Cell Proliferation
Energy Metabolism
Humans
Mammals
metabolism
Mitochondria - metabolism
mitochondrial metabolism
Oxidation-Reduction
oxidation-reduction (redox)
Signal Transduction
Thematic Minireviews
cell metabolism
metabolism
cell proliferation
oxidation-reduction (redox)
mitochondrial metabolism
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Summary:Cell growth and division require nutrients, and proliferating cells use a variety of sources to acquire the amino acids, lipids, and nucleotides that support macromolecule synthesis. Lipids are more reduced than other nutrients, whereas nucleotides and amino acids are typically more oxidized. Cells must therefore generate reducing and oxidizing (redox) equivalents to convert consumed nutrients into biosynthetic precursors. To that end, redox cofactor metabolism plays a central role in meeting cellular redox requirements. In this Minireview, we highlight the biosynthetic pathways that involve redox reactions and discuss their integration with metabolism in proliferating mammalian cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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Edited by Ruma Banerjee
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.TM117.000239