Surface Membrane-Associated Regulation of Cell Assembly, Differentiation, and Growth

• Published in: Blood Vol. 78; no. 2; pp. 264 - 276
• Main Author: Dainiak, Nicholas
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 15.07.1991; The Americain Society of Hematology
• Subjects: Animals; Biological and medical sciences; Cell Communication; Cell Differentiation - physiology; Cell Division - physiology; Cell Membrane - physiology; Cell Membrane - ultrastructure; Cell physiology; Fundamental and applied biological sciences. Psychology; Hematopoiesis; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - physiology; Hematopoietic Stem Cells - ultrastructure; Humans; Molecular and cellular biology; Signal Transduction; Cell proliferation; Regulation(control); Cell differentiation; Association dissociation; Plasma membrane
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V78.2.264.264

The role of the surface membrane in regulating proliferation and differentiation of eukaryotic cells is highly complex. Proximal cell-cell interactions are involved, including physical contact via junctional complexes, exfoliation of surface membrane vesicles, proteolytic cleavage of membrane-bound precursors, and exocytosis of soluble proteins (see Fig 5). At another level, the surface expresses receptors and other proteins that mediate cell-cell adhesion, a multistep event that may be sufficient to activate some growth-associated genes and alter cell shape. The evidence indicates that together with secreted growth factors, surface membrane-associated molecules play a dynamic role in regulating multicellular assembly and cell differentiation and growth.