Precisely synthesized segmented polyurethanes toward block sequence-controlled drug delivery

• Published in: Chemical science (Cambridge) Vol. 13; no. 18; pp. 5353 - 5362
• Main Authors: Song, Yuanqing, Sun, Chuandong, Tian, Chenxu, Ming, Hao, Wang, Yanjun, Liu, Wenkai, He, Nan, He, Xueling, Ding, Mingming, Li, Jiehua, Luo, Feng, Tan, Hong, Fu, Qiang
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 11.05.2022; The Royal Society of Chemistry
• Subjects: Anticancer properties; Biomedical materials; Chemical synthesis; Chemistry; Diisocyanates; Liquid phases; Micelles; Molecular weight; Molecular weight distribution; Polyurethane; Segments; Self-assembly
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/d1sc06457f

The construction of polyurethanes (PUs) with sequence-controlled block structures remains a serious challenge. Here, we report the precise synthesis of PUs with desirable molecular weight, narrow molecular weight distribution, and controlled block sequences from commercially available monomers. The synthetic procedure is derived from a liquid-phase synthetic methodology, which involves diisocyanate-based iterative protocols in combination with a convergent strategy. Furthermore, a pair of multifunctional PUs with different sequence orders of cationic and anion segments were prepared. We show that the sequence order of functional segments presents an impact on the self-assembly behavior and results in unexpected surface charges of assembled micelles, thereby affecting the protein absorption, cell internalization, biodistribution and antitumor effect of the nanocarriers in vitro and in vivo . This work provides a versatile platform for the development of precise multiblock PUs with structural complexity and functional diversity, and will greatly facilitate the clinical translation of PUs in biomedicine. Polyurethanes (PUs) with different segment sequence orders are prepared using a precise synthetic platform, and the sequence order of functional segments plays a crucial role in regulating the surface charges and performance of nano-drug carriers.