Ion channel therapeutics for pain

• Published in: Channels (Austin, Tex.) Vol. 9; no. 6; pp. 344 - 351
• Main Authors: Skerratt, Sarah E, West, Christopher W
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis Group, LLC 02.11.2015
• Subjects: Anesthetics - pharmacology; Anesthetics - therapeutic use; Animals; clinical compounds; drug discovery; Humans; ion channels; Nociception - drug effects; pain; Pain - drug therapy; Review; Sodium Channel Blockers - pharmacology; Sodium Channel Blockers - therapeutic use; sodium channels; Voltage-Gated Sodium Channels - metabolism; pain; drug discovery; sodium channels; clinical compounds; ion channels
• ISSN: 1933-6950; 1933-6969
• DOI: 10.1080/19336950.2015.1075105

Pain is a complex disease which can progress into a debilitating condition. The effective treatment of pain remains a challenge as current therapies often lack the desired level of efficacy or tolerability. One therapeutic avenue, the modulation of ion channel signaling by small molecules, has shown the ability to treat pain. However, of the 215 ion channels that exist in the human genome, with 85 ion channels having a strong literature link to pain, only a small number of these channels have been successfully drugged for pain. The focus of future research will be to fully explore the possibilities surrounding these unexplored ion channels. Toward this end, a greater understanding of ion channel modulation will be the greatest tool we have in developing the next generation of drugs for the treatment of pain.