Comparative Study of Antibiofilm Activity of Copper Oxide and Iron Oxide Nanoparticles Against Multidrug Resistant Biofilm Forming Uropathogens

• Published in: Indian journal of microbiology Vol. 54; no. 3; pp. 365 - 368
• Main Authors: Agarwala, Munin, Choudhury, Bula, Yadav, R. N. S
• Format: Journal Article
• Language: English
• Published: India Springer-Verlag 01.09.2014; Springer India; Springer Nature B.V
• Subjects: Antibacterial agents; antibacterial properties; Antibiotics; Bacteria; biofilm; Biofilms; Biomedical and Life Sciences; Catheters; Comparative studies; Copper; cupric oxide; dose response; E coli; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Iron oxides; Life Sciences; Medical Microbiology; methicillin; Microbiology; multiple drug resistance; Nanoparticles; Short Communication; Staphylococcus aureus; Staphylococcus infections; toxicity; India; Nanoparticles; Biofilm; CuO; Uropathogens; Fe; O; Fe2O3
• ISSN: 0046-8991; 0973-7715
• DOI: 10.1007/s12088-014-0462-z

The effectiveness of the metal oxide nanoparticles viz. CuO and Fe₂O₃as antibacterial agents against multidrug resistant biofilm forming bacteria was evaluated. CuO nanoparticles were also experimented for antibiofilm and time kill assay. The CuO displayed maximum antibacterial activity with zone of inhibition of (22 ± 1) mm against methicillin resistant Staphylococcus aureus (MRSA) followed by Escherichia coli (18 ± 1) mm. The Fe₂O₃showed the zone of inhibition against MRSA of (14 ± 1) mm followed by E. coli (12 ± 1) mm. CuO proved to be more toxic than Fe₂O₃nanoparticles showing significantly high antibacterial activity and found to possess dose dependent antibiofilm properties.