XDH and XO Research and Drug Discovery-Personal History

The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms. However, conversion to XO only occurs in mammals. The molecular mechanism of thi...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 11; p. 4440
Main Author Nishino, Takeshi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 30.05.2023
MDPI
Subjects
Birds
Conversion
Enzyme inhibitors
Enzymes
Experiments
flavine
Gout
Laboratories
Medical research
Molecular modelling
molybdopterin
Nitrogen
non-heme iron
Pharmacology
Poultry
Proteins
R&D
Research & development
Review
Uric acid
xanthine dehydrogenase
xanthine oxidase
COVID-19
flavine
xanthine dehydrogenase
reactive oxygen
purine metabolism
gout
non-heme iron
molybdopterin
uric acid
xanthine oxidase
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Summary:The author will outline the research history of the main issues addressed in this paper. The author has worked on this research himself. XDH, which is responsible for purine degradation, is present in various organisms. However, conversion to XO only occurs in mammals. The molecular mechanism of this conversion was elucidated in this study. The physiological and pathological significance of this conversion is presented. Finally, enzyme inhibitors were successfully developed, two of which are used as therapeutic agents for gout. Their wide application potential is also discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28114440