Fe and Zn co-substituted beta-tricalcium phosphate (β-TCP): Synthesis, structural, magnetic, mechanical and biological properties

• Published in: Materials Science & Engineering C Vol. 112; p. 110918
• Main Authors: Sinusaite, Lauryna, Popov, Anton, Antuzevics, Andris, Mazeika, Kestutis, Baltrunas, Dalis, Yang, Jen-Chang, Horng, Jiun Lin, Shi, Shengfang, Sekino, Tohru, Ishikawa, Kunio, Kareiva, Aivaras, Zarkov, Aleksej
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2020; Elsevier BV
• Subjects: Animals; Beta-tricalcium phosphate; Biocompatibility; Biological properties; Calcium ions; Calcium phosphates; Calcium Phosphates - chemical synthesis; Calcium Phosphates - chemistry; Calcium Phosphates - pharmacology; Ceramic powders; Chemical synthesis; Crystallography; Cytotoxicity; Danio rerio; Decomposition; Diamond pyramid hardness; Electron paramagnetic resonance; Electron spin resonance; Embryo, Nonmammalian - drug effects; Fe3+ and Zn2+ co-substitution; Ferric ions; Hardness; Ions; Iron; Iron - chemistry; Lattice parameters; Magnetic properties; Magnetics; Materials science; Mechanical properties; Powders - chemistry; Precipitates; Raman spectra; Raman spectroscopy; Spectroscopy, Mossbauer; Spectrum analysis; Spectrum Analysis, Raman; Structural analysis; Substitutes; Temperature; Thermal decomposition; Toxicity; Tricalcium phosphate; Zebrafish; Zebrafish - growth & development; Zinc; Zinc - chemistry; Fe3+ and Zn2+ co-substitution; Cytotoxicity; Beta-tricalcium phosphate; Structural analysis; Magnetic properties; Fe(3+) and Zn(2+) co-substitution
• ISSN: 0928-4931; 1873-0191; 1873-0191
• DOI: 10.1016/j.msec.2020.110918

In the present work, Fe3+ and Zn2+ co-substituted β-tricalcium phosphate (β-TCP) has been synthesized by wet co-precipitation method. Co-substitution level in the range from 1 to 5 mol% has been studied. Thermal decomposition of as-prepared precipitates was shown to be affected by introducing of foreign ions, decreasing the decomposition temperature of precursor. It was determined that partial substitution of Ca2+ by Fe3+ and Zn2+ ions leads to the change in lattice parameters, which gradually decrease as doping level increases. Lattice distortion was also confirmed by means of Raman spectroscopy, which showed gradual change of the peaks shape in the Raman spectra. Rietveld refinement and electron paramagnetic resonance study confirmed that Fe3+ ions occupy only one Ca crystallographic site until Fe3+ and Zn2+ substitution level reaches 5 mol%. All co-substituted samples revealed paramagnetic behavior, magnetization of powders was determined to be linearly dependent on concentration of Fe3+ ions. Cytotoxicity of the synthesized species was estimated by in vivo assay using zebrafish (Danio rerio) and revealed non-toxic nature of the samples. Preparation of ceramic bodies from the powders was performed, however the results obtained on Vickers hardness of the ceramics did not show improvement in mechanical properties induced by co-substitution. •Fe3+ and Zn2+ co-substituted β-TCP has been synthesized for the first time•All co-substituted samples revealed paramagnetic behavior•Cytotoxicity test revealed non-toxic nature of the samples