The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

Signals released by the Spemann organizer of the amphibian gastrula can directly induce neural tissue from ectoderm and can dorsalize ventral mesoderm to form muscle. The secreted polypeptide noggin mimics these activities and is expressed at the appropriate time and place to participate in the orga...

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Published inCell Vol. 86; no. 4; pp. 599 - 606
Main Authors Zimmerman, Lyle B, De Jesús-Escobar, José M, Harland, Richard M
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 23.08.1996
Subjects
Animals
Base Sequence
Bone Marrow Cells
Bone Morphogenetic Protein Receptors
Bone Morphogenetic Proteins
Carrier Proteins
Cells, Cultured
DNA Primers - chemistry
Immunologic Techniques
Mice
Molecular Sequence Data
Protein Binding
Proteins - antagonists & inhibitors
Proteins - metabolism
Proteins - physiology
Receptors, Cell Surface - metabolism
Receptors, Growth Factor
Signal Transduction
Xenopus laevis - embryology
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Summary:Signals released by the Spemann organizer of the amphibian gastrula can directly induce neural tissue from ectoderm and can dorsalize ventral mesoderm to form muscle. The secreted polypeptide noggin mimics these activities and is expressed at the appropriate time and place to participate in the organizer signal. Neural induction and mesoderm dorsalization are antagonized by bone morphogenetic proteins (BMPs), which induce epidermis and ventral mesoderm instead. Here we report that noggin protein binds BMP4 with high affinity and can abolish BMP4 activity by blocking binding to cognate cell-surface receptors. These data suggest that noggin secreted by the organizer patterns the embryo by interrupting BMP signaling.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)80133-6