In Vitro Activities of Daptomycin, Ciprofloxacin, and Other Antimicrobial Agents against the Cells and Spores of Clinical Isolates of Bacillus Species

Daptomycin inhibited 67 of 70 clinical isolates of Bacillus species at <=1 μg/ml and 100% of them at <=2 μg/ml. It showed bactericidal activity similar to that of ciprofloxacin against vegetative cells but not against spores. For 2 strains, the ciprofloxacin MICs were >4 g/ml, and 10 strain...

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Published inJournal of Clinical Microbiology Vol. 44; no. 10; pp. 3814 - 3818
Main Authors Citron, Diane M, Appleman, Maria D
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.10.2006
Subjects
Anti-Bacterial Agents - pharmacology
Bacillus
Bacillus - drug effects
Bacteriology
Biological and medical sciences
Ciprofloxacin - pharmacology
Daptomycin - pharmacology
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Infectious diseases
Medical sciences
Microbial Sensitivity Tests
Microbiology
Spores, Bacterial - drug effects
Antibiotic
Bacillales
Microbiology
Bacillus
Daptomycin
Bacteria
Bacillaceae
Antibacterial agent
Ciprofloxacin
Clinical isolate
Antimicrobial agent
Spores
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Summary:Daptomycin inhibited 67 of 70 clinical isolates of Bacillus species at <=1 μg/ml and 100% of them at <=2 μg/ml. It showed bactericidal activity similar to that of ciprofloxacin against vegetative cells but not against spores. For 2 strains, the ciprofloxacin MICs were >4 g/ml, and 10 strains were resistant to erythromycin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Corresponding author. Mailing address: Microbial Research Lab, 2G-24, LAC+USC Medical Center, 1801 Marengo Street, Los Angeles, CA 90033. Phone: (323) 226-3749. Fax: (323) 226-7021. E-mail: dcitron@usc.edu.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.00881-06