The association between interleukin-19 concentration and diabetic nephropathy

• Published in: BMC nephrology Vol. 18; no. 1; p. 65
• Main Authors: Li, Li, Jiang, Xu-gan, Hu, Juan-Yu, Yu, ZHeng-Qing, Xu, Jian-Yong, Liu, Fan, Zhao, Guang-Chun, Zhang, Lei, Gu, Hui-Ming, Zhang, Si-Jing, Meng, Jin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.02.2017; BioMed Central
• Subjects: Albuminuria; Analysis; Biomarkers - blood; China - epidemiology; Development and progression; Diabetic nephropathies; Diabetic Nephropathies - blood; Diabetic Nephropathies - diagnosis; Diabetic Nephropathies - epidemiology; Female; Health aspects; Humans; Inflammation; Interleukins; Interleukins - blood; Male; Middle Aged; Nephrology; Physiological aspects; Prevalence; Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Type 2 diabetes; China; Diabetic nephropathy; High-sensitivity C-reactive protein; Albuminuria; Interleukin-19
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-017-0488-7

Interleukin-19 (IL-19) is a newly discovered cytokine belonging to the Interleukin-10(IL-10) family. IL-19 have indispensable functions in many inflammatory processes and also can induce the angiogenic potential of endothelial cells. The purpose of present study was to investigate the relation of serum interleukin-19 (IL-19) levels with diabetic nephropathy (DN). Two hundred study groups of patients with type 2 diabetes mellitus (T2DM) (109 males and 91 females) were recruited, included normoalbuminuria(n = 102), microalbuminuria(n = 72) and macroalbuminuria(n = 26) . The 50 healthy blood donors were enrolled for the control group. All subjects were assessed for: IL-19, High-sensitivity C-reactive protein (Hs-CRP), Cystatin C, urinary albumin excretion rate (UAE) and glycosylated hemoglobin A1c(HbA1c). The serum IL-19 levels in DN patients were found to be significantly higher compared to controls. IL-19 levels were significantly positively correlated with Hs-CRP, Cystatin C, UAE and HbA1c(r = 0.623, 0.611,0.591 and 0.526 respectively, P < 0.01). Multivariable logistic regression analysis showed IL-19 levels (P = 0.01) were found to be independently associated with patients with DN. IL-19 is significantly positive correlated with UAE and Cystatin C. IL-19 may play an important role that contributes to the progression of diabetic nephropathy.