Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5

• Published in: Atherosclerosis Vol. 235; no. 2; pp. 592 - 598
• Main Authors: Wan, Min, Hua, Xiang, Su, Jun, Thiagarajan, Divya, Frostegård, Anna G, Haeggström, Jesper Z, Frostegård, Johan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.08.2014
• Subjects: Annexin A5 - metabolism; Annexin A5 - pharmacology; Arachidonate 5-Lipoxygenase - metabolism; Atherosclerosis; Calcium - metabolism; Cardiolipin; Cardiolipins - metabolism; Cardiolipins - pharmacology; Cardiovascular; Humans; Inflammation; Inflammation - chemically induced; Inflammation Mediators - pharmacology; Intercellular Adhesion Molecule-1 - biosynthesis; Leukocytes, Mononuclear - metabolism; Leukotriene B4 - biosynthesis; Leukotrienes; Macrophages - metabolism; Medicin och hälsovetenskap; Neutrophils - metabolism; Oxidation; Oxidation-Reduction; Vascular Cell Adhesion Molecule-1 - biosynthesis; Oxidation; Inflammation; Cardiolipin; Leukotrienes; Atherosclerosis

Abstract Objective Cardiolipin (CL) is a phospholipid with an unusual dimeric structure containing four double-bonds and is easily oxidized. CL is present in mitochondria. Here we explored potential pro-inflammatory properties implicated in cardiovascular disease (CVD): activation of endothelial cel...