Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility

• Published in: Scientific reports Vol. 10; no. 1; p. 16987
• Main Authors: Schulte, Alina, Thiel, Christiane M., Gieseler, Anja, Tahden, Maike, Colonius, Hans, Rosemann, Stephanie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.10.2020
• Subjects: 631/378; 631/477; Aged; Aged, 80 and over; Auditory Perception; Brain Mapping; Female; Humanities and Social Sciences; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex - diagnostic imaging; multidisciplinary; Nerve Net - diagnostic imaging; Nerve Net - physiology; Neural Pathways; Presbycusis - diagnosis; Science; Science (multidisciplinary); Visual Cortex - diagnostic imaging; Visual Perception
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-74012-0

Age-related hearing loss has been related to a compensatory increase in audio-visual integration and neural reorganization including alterations in functional resting state connectivity. How these two changes are linked in elderly listeners is unclear. The current study explored modulatory effects of hearing thresholds and audio-visual integration on resting state functional connectivity. We analysed a large set of resting state data of 65 elderly participants with a widely varying degree of untreated hearing loss. Audio-visual integration, as gauged with the McGurk effect, increased with progressing hearing thresholds. On the neural level, McGurk illusions were negatively related to functional coupling between motor and auditory regions. Similarly, connectivity of the dorsal attention network to sensorimotor and primary motor cortices was reduced with increasing hearing loss. The same effect was obtained for connectivity between the salience network and visual cortex. Our findings suggest that with progressing untreated age-related hearing loss, functional coupling at rest declines, affecting connectivity of brain networks and areas associated with attentional, visual, sensorimotor and motor processes. Especially connectivity reductions between auditory and motor areas were related to stronger audio-visual integration found with increasing hearing loss.