Chromatin: The Final Frontier in Splicing Regulation?

Pre-mRNA splicing, once thought to be a strictly posttranscriptional event in gene expression, is subject to a multitiered network of regulation. Luco et al. now report in Science that this regulation seems to begin with chromatin modifications, suggesting that the histone code may be a prequel to t...

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Bibliographic Details
Published inDevelopmental cell Vol. 18; no. 3; pp. 336 - 338
Main Authors Fox-Walsh, Kristi, Fu, Xiang-Dong
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.03.2010
Subjects
Alternative Splicing
Chromatin - genetics
Chromatin - metabolism
Histones - genetics
Histones - metabolism
Humans
Mesenchymal Stem Cells - metabolism
Models, Biological
Polypyrimidine Tract-Binding Protein - metabolism
Receptor, Fibroblast Growth Factor, Type 2 - genetics
RNA Interference
RNA Precursors - genetics
RNA Precursors - metabolism
RNA Splicing - genetics
RNA Splicing - physiology
Online AccessGet full text
ISSN1534-5807
1878-1551
1878-1551
DOI10.1016/j.devcel.2010.03.002

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Summary:Pre-mRNA splicing, once thought to be a strictly posttranscriptional event in gene expression, is subject to a multitiered network of regulation. Luco et al. now report in Science that this regulation seems to begin with chromatin modifications, suggesting that the histone code may be a prequel to the splicing code.
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ISSN:1534-5807
1878-1551
1878-1551
DOI:10.1016/j.devcel.2010.03.002