Carcinogenic and neurotoxic risks of acrylamide consumed through caffeinated beverages among the lebanese population

• Published in: Chemosphere (Oxford) Vol. 208; pp. 352 - 357
• Main Authors: El-Zakhem Naous, Ghada, Merhi, Areej, Abboud, Martine I., Mroueh, Mohamad, Taleb, Robin I.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2018
• Subjects: Acrylamide; American coffee; Caffeinated beverages; Carcinogenic; Espresso; Gas chromatography mass spectrometry; Lebanese coffee; Neurotoxic; Carcinogenic; Gas chromatography mass spectrometry; Acrylamide; Caffeinated beverages; American coffee; Espresso; Lebanese coffee; Neurotoxic
• ISSN: 0045-6535; 1879-1298
• DOI: 10.1016/j.chemosphere.2018.05.185

The present study aims to quantify acrylamide in caffeinated beverages including American coffee, Lebanese coffee, espresso, instant coffee and hot chocolate, and to determine their carcinogenic and neurotoxic risks. A survey was carried for this purpose whereby 78% of the Lebanese population was found to consume at least one type of caffeinated beverages. Gas Chromatography Mass Spectrometry analysis revealed that the average acrylamide level in caffeinated beverages is 29,176 μg/kg sample. The daily consumption of acrylamide from Lebanese coffee (10.9 μg/kg-bw/day), hot chocolate (1.2 μg/kg-bw/day) and Espresso (7.4 μg/kg-bw/day) was found to be higher than the risk intake for carcinogenicity and neurotoxicity as set by World Health Organization (WHO; 0.3–2 μg/kg-bw/day) at both the mean (average consumers) and high (high consumers) dietary exposures. On the other hand, American coffee (0.37 μg/kg-bw/day) was shown to pose no carcinogenic or neurotoxic risks among the Lebanese community for consumers with a mean dietary exposure. The study shows alarming results that call for regulating the caffeinated product industry by setting legislations and standard protocols for product preparation in order to limit the acrylamide content and protect consumers. In order to avoid carcinogenic and neurotoxic risks, we propose that WHO/FAO set acrylamide levels in caffeinated beverages to 7000 μg acrylamide/kg sample, a value which is 4-folds lower than the average acrylamide levels of 29,176 μg/kg sample found in caffeinated beverages sold in the Lebanese market. Alternatively, consumers of caffeinated products, especially Lebanese coffee and espresso, would have to lower their daily consumption to 0.3–0.4 cups/day. •High acrylamide levels in caffeinated beverages sold in the Lebanese market.•Acrylamide level in caffeinated beverages is 29,176 μg/kg sample.•Consumption of acrylamide from caffeinated products is carcinogenic and neurotoxic.•WHO should set acrylamide levels in caffeinated products to 7000 μg/kg sample.