Optic Neuritis in Multiple Sclerosis—A Review of Molecular Mechanisms Involved in the Degenerative Process

Multiple sclerosis is a central nervous system inflammatory demyelinating disease with a wide range of clinical symptoms, ocular involvement being frequently marked by the presence of optic neuritis (ON). The emergence and progression of ON in multiple sclerosis is based on various pathophysiologica...

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Published inCurrent Issues in Molecular Biology Vol. 44; no. 9; pp. 3959 - 3979
Main Authors Ciapă, Manuela Andreea, Șalaru, Delia Lidia, Stătescu, Cristian, Sascău, Radu Andy, Bogdănici, Camelia Margareta
Format Journal Article
LanguageEnglish
Published MDPI AG 01.09.2022
MDPI
Subjects
Analysis
axonal degeneration
B cells
demyelination
Development and progression
Health aspects
Inflammation
molecular mechanisms
Multiple sclerosis
Optic neuritis
remyelination
Review
Romania
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Summary:Multiple sclerosis is a central nervous system inflammatory demyelinating disease with a wide range of clinical symptoms, ocular involvement being frequently marked by the presence of optic neuritis (ON). The emergence and progression of ON in multiple sclerosis is based on various pathophysiological mechanisms, disease progression being secondary to inflammation, demyelination, or axonal degeneration. Early identification of changes associated with axonal degeneration or further investigation of the molecular processes underlying remyelination are current concerns of researchers in the field in view of the associated therapeutic potential. This article aims to review and summarize the scientific literature related to the main molecular mechanisms involved in defining ON as well as to analyze existing data in the literature on remyelination strategies in ON and their impact on long-term prognosis.
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ISSN:1467-3045
1467-3037
1467-3045
DOI:10.3390/cimb44090272