Anticipatory Control of Manipulative Forces in Parkinson's Disease

• Published in: Experimental neurology Vol. 145; no. 2; pp. 477 - 488
• Main Authors: Gordon, Andrew M., Ingvarsson, Páll E., Forssberg, Hans
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.06.1997; Elsevier
• Subjects: Biological and medical sciences; Conditioning (Psychology) - physiology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Electrophysiology; Hand Strength; Humans; Isometric Contraction - physiology; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Movement - physiology; Neurology; Parkinson Disease - physiopathology; Weight-Bearing; Human; Nervous system diseases; Check; Parkinson disease; Isometric muscular contraction; Anticipation; Cerebral disorder; Functional capacity; Accuracy; Manipulation; Central nervous system disease; Body movement; Degenerative disease; Extrapyramidal syndrome
• ISSN: 0014-4886; 1090-2430
• DOI: 10.1006/exnr.1997.6479

In a previous study we found that subjects with Parkinson's disease (PD) had an impaired capability to initiate and sequence successive movement phases during lifts of small objects using the precision grip, and that they had regular oscillations in the force rates. The present study examined whether these subjects could use anticipatory control, in which the force output is scaled prior to liftoff, based on the object's physical properties. Subjects lifted an instrumented test object between the tips of the thumb and index finger while the employed grip force, load force (vertical lifting force), and corresponding time derivatives were recorded. In the first experiment, the object's weight was varied to assess its influence on the isometric force output. Subjects with PD scaled the isometric force increase according to the object's weight. In another experiment, the weight changed in proportion to the volume to determine whether subjects could make associative transformations between visual size information and the weight of the object. Subjects with PD still scaled the forces toward the expected weight, proportional to the volume of the object. Finally, programmed adjustments in force to sudden self-induced load changes were examined while subjects dropped a disk with one hand into a plate attached to the bottom of the grip instrument, held with the other hand. Subjects with PD had preparatory increases in the grip force prior to the disk contact, which matched the change in load, though may have been more dependent on visual feedback. We conclude that subjects with PD are capable of using anticipatory control to parameterize the isometric force output during a familiar lifting task.