Label-Free Sensing of Biomolecular Adsorption and Desorption Dynamics by Interfacial Second Harmonic Generation

Observing interfacial molecular adsorption and desorption dynamics in a label-free manner is fundamentally important for understanding spatiotemporal transports of matter and energy across interfaces. Here, we report a label-free real-time sensing technique utilizing strong optical second harmonic g...

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Published inBiosensors (Basel) Vol. 12; no. 11; p. 1048
Main Authors Xia, Chuansheng, Sun, Jianli, Wang, Qiong, Chen, Jinping, Wang, Tianjie, Xu, Wenxiong, Zhang, He, Li, Yuanyuan, Chang, Jianhua, Shi, Zengliang, Xu, Chunxiang, Cui, Qiannan
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 20.11.2022
MDPI
Subjects
Adsorption
adsorption and desorption
biomolecule
Biomolecules
Biosensors
bovine serum albumin
Chemical properties
Chemical vapor deposition
Desorption
Electronics industry
Engineering research
heterointerface
Interfaces
Lasers
Measurement
Microscopy
Molybdenum disulfide
Monolayers
Second harmonic generation
Semiconductors
Spatial discrimination
Spatial resolution
Spectrum analysis
Symmetry
China
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Summary:Observing interfacial molecular adsorption and desorption dynamics in a label-free manner is fundamentally important for understanding spatiotemporal transports of matter and energy across interfaces. Here, we report a label-free real-time sensing technique utilizing strong optical second harmonic generation of monolayer 2D semiconductors. BSA molecule adsorption and desorption dynamics on the surface of monolayer MoS2 in liquid environments have been all-optically observed through time-resolved second harmonic generation (SHG) measurements. The proposed SHG detection scheme is not only interface specific but also expected to be widely applicable, which, in principle, undertakes a nanometer-scale spatial resolution across interfaces.
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ISSN:2079-6374
2079-6374
DOI:10.3390/bios12111048