Spray-dried microspheres containing ketoprofen formulated into capsules and tablets

• Published in: Journal of microencapsulation Vol. 18; no. 1; pp. 111 - 121
• Main Authors: MORETTI, M. D. L, GAVINI, E, JULIANO, C, PIRISINO, G, GIUNCHEDI, P
• Format: Journal Article
• Language: English
• Published: Colchester Informa UK Ltd 2001; Taylor & Francis; Informa
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Capsules; Cellulose - analogs & derivatives; General pharmacology; Ketoprofen - administration & dosage; Ketoprofen - chemistry; Ketoprofen Spray-DRYING Microspheres Tabletting Controlled Drug Delivery; Light; Medical sciences; Microscopy, Electron, Scanning; Microspheres; Molecular Weight; Particle Size; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Scattering, Radiation; Tablets; Encapsulation; Particle size; Microsphere; Pharmaceutical technology; Controlled release form; Control release polymer; Spray drying; Oral form; Drug carrier; Capsule; Direct compression; In vitro; Ketoprofen; Non steroidal antiinflammatory agent; Cellulose acetate butyrate; Formulation; Cellulose derivatives; Dosage form; pH; Arylpropionic acid derivatives; Active ingredient; Tablet; Release; Physicochemical properties
• ISSN: 0265-2048; 1464-5246
• DOI: 10.1080/026520401750038647

In this study, microspheres were prepared by a spray-drying technique using solutions of ketoprofen and two polymers, cellulose acetate butyrate (CAB) and hydroypropylmethylcellulose phthalate (HPMCP), in different weight ratios. Different total concentrations were used in the feed solutions: 3, 6 and 9% w/v. The spray-dried microparticles were characterized in terms of shape (SEM), size (light scattering method), production yield and encapsulation efficiency. They were formulated into capsules; tablets were prepared by direct compression of the microparticles mixed with maltose and, in some cases, hydroypropylmethylcellulose (HPMC). In vitro release studies were performed both at acidic and neutral pHs. The spray-drying process of solutions of ketoprofen with polymeric blends of cellulose derivatives leads to microparticles which, depending on their final formulation (capsules or tablets), can give a rapid or prolonged drug release. The formulations here described can be proposed for the oral administration of NSAIDs.