The time course and phenotype of Uhthoff phenomenon following optic neuritis

• Published in: Multiple sclerosis Vol. 18; no. 7; pp. 1042 - 1044
• Main Authors: Fraser, Clare L, Davagnanam, Indran, Radon, Mark, Plant, Gordon T
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2012; Sage Publications; Sage Publications Ltd
• Subjects: Adult; Biological and medical sciences; Body Temperature; Clinical trials; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Drugs; Female; Humans; Injuries of the nervous system and the skull. Diseases due to physical agents; Inventories; Male; Medical sciences; Motor Activity - physiology; Multiple sclerosis; Multiple Sclerosis - complications; Multiple Sclerosis - physiopathology; Myelination; Neurology; Optic neuritis; Optic Neuritis - complications; Optic Neuritis - physiopathology; Phenotype; Surveys and Questionnaires; Time; Traumas. Diseases due to physical agents; heat; temperature; Uhthoff; multiple sclerosis; optic neuritis; Nervous system diseases; Multiple sclerosis; Temperature; Optic nerve; Optic neuritis; Inflammatory disease; Eye disease; Phenotype; Cranial nerve disease; Visual pathway; Optic nevritis; Central nervous system disease; Degenerative disease
• ISSN: 1352-4585; 1477-0970
• DOI: 10.1177/1352458511431074

As there is little information regarding the recovery from Uhthoff phenomenon (UP) in the multiple sclerosis (MS) literature, the objective of this study was to assess the phenotypes of UP. A one-page questionnaire was sent to 80 consecutive optic neuritis (ON) patients seen in a tertiary neuro-ophthalmology clinic. Of the 48 responders to the questionnaire, 52% reported experiencing UP, with a range of follow-up from 1 to 20 years. Only 16% had resolution of UP, all this occurred within 8 weeks of the onset of ON. Of the MS patients with UP, 88% experienced non-visual heat-related phenomenon compared with 30% without UP. The presence of UP may have a more general phenotypic significance. If full recovery from UP has not occurred within the first 2 months from the onset of ON, then recovery appears to be uncommon and may therefore be a surrogate marker of remyelination in future drug trials.