Evaluation of focal defects of the nerve fiber layer using optical coherence tomography

• Published in: Ophthalmology (Rochester, Minn.) Vol. 106; no. 3; pp. 570 - 579
• Main Authors: Pieroth, Liselotte, Schuman, Joel S, Hertzmark, Ellen, Hee, Michael R, Wilkins, Jason R, Coker, Jeffrey, Mattox, Cynthia, Pedut-Kloizman, Tamar, Puliafito, Carmen A, Fujimoto, James G, Swanson, Eric
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.1999; Elsevier
• Subjects: Biological and medical sciences; Cross-Sectional Studies; Diagnostic Techniques, Ophthalmological - instrumentation; Female; Fundus Oculi; Glaucoma - diagnosis; Glaucoma and intraocular pressure; Humans; Image Processing, Computer-Assisted; Male; Medical sciences; Middle Aged; Nerve Fibers - pathology; Ophthalmology; Optic Disk - pathology; Optic Nerve - pathology; Optic Nerve Diseases - diagnosis; Tomography - methods; Visual Fields; Human; Nervous system diseases; Optic nerve; Prevalence; Radiodiagnosis; Substance loss; Exploration; Thickness; Eye disease; Cranial nerve disease; Light coherence; Glaucoma (eye); Cross sectional study; Tomography; Nerve fiber
• ISSN: 0161-6420; 1549-4713
• DOI: 10.1016/S0161-6420(99)90118-5

To analyze glaucomatous eyes with known focal defects of the nerve fiber layer (NFL), relating optical coherence tomography (OCT) findings to clinical examination, NFL and stereoscopic optic nerve head (ONH) photography, and Humphrey 24–2 visual fields. Cross-sectional prevalence study. The authors followed 19 patients in the study group and 14 patients in the control group. Imaging with OCT was performed circumferentially around the ONH with a circle diameter of 3.4 mm using an internal fixation technique. One hundred OCT scan points taken within 2.5 seconds were analyzed. Measurements of NFL thickness using OCT were performed. In most eyes with focal NFL defects, OCTs showed significant thinning of the NFL in areas closely corresponding to focal defects visible on clinical examination, to red-free photographs, and to defects on the Humphrey visual fields. Optical coherence tomography enabled the detection of focal defects in the NFL with a sensitivity of 65% and a specificity of 81%. Analysis of NFL thickness in eyes with focal defects showed good structural and functional correlation with clinical parameters. Optical coherence tomography contributes to the identification of focal defects in the NFL that occur in early stages of glaucoma.