Extending the limits of Bacillus for novel biotechnological applications

• Published in: Biotechnology advances Vol. 31; no. 8; pp. 1543 - 1561
• Main Authors: Kumar, Prasun, Patel, Sanjay K.S., Lee, Jung-Kul, Kalia, Vipin C.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Inc 01.12.2013; Elsevier
• Subjects: Bacillus; bioactive properties; biofuels; Biohydrogen; Biological and medical sciences; Biotechnology; Co-culture; Co-polymers; environmental factors; Fundamental and applied biological sciences. Psychology; hydrogen; industrial applications; Industrial Microbiology; Metabolic co-operation; Polyhydroxyalkanoate; Polyhydroxyalkanoates; Polyhydroxybutyrate; Quorum quenching; Quorum Sensing; racehorses; therapeutics; Mn; 3OC4HSL; 3OC6HSL; AHL; C5HSL; HO; C7HSL; 3OC8HSL; PHA; HDD; PHB; BHP; HV; Metabolic co-operation; Bacillus; Quorum sensing; HAs; HSL; C10HSL; C12HSL; Biohydrogen; C8HSL; C6HSL; 3OHC4HSL; Quorum quenching; Polyhydroxybutyrate; 3OHC12HSL; Polyhydroxyalkanoate; C4HSL; HHx; DCW; HB; HD; Co-culture; 3OC10HSL; 3OC12HSL; Co-polymers; Biotechnology; Hydrogen; Ester polymer; Alkanoate(hydroxy) polymer; Butyrate(hydroxy)polymer; Polymer; Bacillaceae; Metabolism; Bacillales; Bacteria; Application; Culture; N-decanoyl-HSL; Biological hydrogen production; Homoserine lactone; 3-oxo-N-decanoyl-HSL; M(n); N-octanoyl-HSL; 3-oxo-N-butanoyl-HSL; 3-oxo-N-dodecanoyl-HSL; N-pentanoyl-HSL; Hydroxybutyrate; Hydroxydodecanoate; Hydroxydecanoate; Number average molecular weight; Hydroxyvalerate; 3-oxo-N-hexanoyl-HSL; Hydroxyoctanoate; N-butanoyl HSL; N-hexanoyl-HSL; Hydroxyacids; Hydroxyhexanoate; 3-oxo-N-octanoyl-HSL; N-heptanoyl-HSL; 3-hydroxydodecanoyl-HSL; Dry cell weight; N-dodecanoyl-HSL; Acylhomoserine lactone; 3-hydroxybutanoyl-HSL
• ISSN: 0734-9750; 1873-1899
• DOI: 10.1016/j.biotechadv.2013.08.007

Bacillus, generally regarded as safe, has emerged as a robust organism that can withstand adverse environmental conditions and grows easily to very high densities. Bacillus has been recognized for its biotechnological applications on an industrial scale. Recent efforts have shown the potential of Bacillus to generate biofuels (hydrogen), biopolymers (polyhydroxyalkanoates), and bioactive molecules (acyl-homoserine lactonases). Bacillus can be considered the dark horse in the race to generate sustainable energy, ecofriendly non-fossil fuel-based polymers, and bioactive molecules for use as therapeutics. •Potential of Bacillus to produce biohydrogen•Biopolymer production from biowastes•Strategies for enhancing polyhydroxyalkanoate (PHA) characteristics•Quorum quenching abilities of Bacillus•Heterologous expression of acylhomoserine lactone (AHL) — lactonases