Morning blood pressure surge and target organ damage in newly diagnosed type 2 diabetic patients: a cross sectional study

• Published in: BMC endocrine disorders Vol. 15; no. 1; p. 77
• Main Authors: Lyhne, Johanne M, Laugesen, Esben, Høyem, Pernille, Cichosz, Simon, Christiansen, Jens S, Knudsen, Søren T, Hansen, Klavs W, Hansen, Troels K, Poulsen, Per L
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.12.2015; BioMed Central
• Subjects: Blood pressure; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory; Brain damage; Cardiovascular Diseases - etiology; Care and treatment; Case-Control Studies; Circadian Rhythm - physiology; Comparative analysis; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetes therapy; Diabetic Angiopathies - etiology; Diabetics; Female; Follow-Up Studies; Humans; Hypertension; Male; Measurement; Medical research; Medicine, Experimental; Middle Aged; Prognosis; Risk Factors; Type 2 diabetes; Wave propagation
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-015-0068-4

Type 2 diabetic patients display significantly higher incidence of cardiovascular (CV) events including stroke compared to non-diabetics. Morning blood pressure surge (MBPS) and blunted systolic night-day (SND) ratio have been associated with CV events in hypertensive patients. No studies have evaluated MBPS in newly diagnosed diabetic patients or studied the association with vascular target organ damage at this early time point of the diabetes disease. Ambulatory blood pressure monitoring was performed in 100 patients with newly diagnosed type 2 diabetes and 100 age and sex matched controls. MBPS and SND-ratio were calculated. Markers of early vascular target organ damage included pulse wave velocity (PWV), white matter lesions (WML) on brain MRI, and urine albumin/creatinine ratio (UAE). No significant differences in MBPS were found between diabetic patients and controls. Neither MBPS or SND-ratio were associated with PWV, UAE or WML in the diabetic group independently of age, gender and 24-h systolic blood pressure. 40.2 % of diabetic patients and 25.8 % of controls were classified as non-dippers (p = 0.03). MBPS and SND-ratio are not associated with subclinical markers of vascular target organ damage in our study sample of newly diagnosed type 2 diabetic patients.