Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control study

• Published in: The American journal of clinical nutrition Vol. 95; no. 4; pp. 944 - 950
• Main Authors: Touvier, Mathilde, Kesse-Guyot, Emmanuelle, Andreeva, Valentina A, Fezeu, Léopold, Charnaux, Nathalie, Sutton, Angela, Druesne-Pecollo, Nathalie, Hercberg, Serge, Galan, Pilar, Zelek, Laurent, Latino-Martel, Paule, Czernichow, Sébastien
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutrition 01.04.2012; American Society for Clinical Nutrition, Inc; Oxford University Press
• Subjects: adhesion; administration & dosage; Anticarcinogenic Agents; Anticarcinogenic Agents - administration & dosage; Biological and medical sciences; Biomarkers, Tumor; Biomarkers, Tumor - blood; blood; Breast Neoplasms; Breast Neoplasms - blood; Breast Neoplasms - epidemiology; Breast Neoplasms - prevention & control; breasts; Cancer; Carcinogenesis; Carcinogens; Case-Control Studies; Cell adhesion & migration; chemistry; Cohort Studies; Diet Records; Diets; Double-Blind Method; epidemiology; experimental design; Fatty acids; Fatty Acids, Omega-3; Fatty Acids, Omega-3 - administration & dosage; Feeding. Feeding behavior; Female; Follow-Up Studies; France; France - epidemiology; Fundamental and applied biological sciences. Psychology; Humans; Incidence; Intercellular Adhesion Molecule-1; Intercellular Adhesion Molecule-1 - blood; Intercellular Adhesion Molecule-1 - chemistry; Life Sciences; Male; Middle Aged; Neoplasms; Neoplasms - blood; Neoplasms - epidemiology; Neoplasms - prevention & control; Nutrition; polyunsaturated fatty acids; prevention & control; Prostate cancer; prostatic neoplasms; Prostatic Neoplasms - blood; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - prevention & control; regression analysis; Risk; Risk factors; Solubility; Vertebrates: anatomy and physiology, studies on body, several organs or systems; France; Human; Association; Intercellular adhesion molecule 1; Modulation; Risk factor; Case control study; Malignant tumor; Cancer; Blood plasma; BREAST-CANCER; ENDOTHELIAL DYSFUNCTION; DOCOSAHEXAENOIC ACID; COLORECTAL-CANCER; PROSTATE-CANCER; SERUM-LEVELS; POLYUNSATURATED FATTY-ACIDS; MECHANISMS; TUMOR-GROWTH; ALPHA-LINOLENIC ACID
• ISSN: 0002-9165; 1938-3207; 1938-3207
• DOI: 10.3945/ajcn.111.027805

Mechanistic data suggest that n-3 PUFAs and endothelial function may interact and play a role in carcinogenesis, but epidemiologic evidence is lacking. Our objective was to investigate whether the prospective association between soluble intercellular adhesion molecule-1 (sICAM-1) and cancer risk is modulated by n-3 PUFA intake. A nested case-control study was designed to include all first-incident cancer cases diagnosed in the SUpplémentation en VItamines et Minéraux AntioXydants cohort between 1994 and 2007, with available dietary data from 24-h records (n = 408). Cases were matched with 1 or 2 randomly selected controls (n = 760). Conditional logistic regression was used to estimate ORs and 95% CIs for the association between prediagnostic plasma concentrations of sICAM-1 and cancer risk, stratified by n-3 PUFA intake. The interactions between sICAM-1 and n-3 PUFA intake were tested. An interaction was observed between sICAM-1 and n-3 PUFA intake, which was consistent across the studied cancer locations (P-interaction = 0.036 for overall, 0.038 for breast, and 0.020 for prostate cancer risk). sICAM-1 concentrations were positively associated with cancer risk among subjects with n-3 PUFA intakes below the median (multivariate OR(Tertile3vsTertile1): 2.8; 95% CI: 1.5, 5.2; P-trend = 0.001), whereas this association was not observed for subjects with n-3 PUFA intakes above the median (OR(Tertile3vsTertile1): 1.3; 95% CI: 0.8, 2.3; P-trend = 0.3). These findings suggest that n-3 PUFA intake may counteract the procarcinogenic actions of sICAM-1.