Partially Purified Extracts of Sea Anemone Anemonia viridis Affect the Growth and Viability of Selected Tumour Cell Lines

In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone Anemonia viridis. Four different fractions were evaluated for their cy...

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Published inBioMed research international Vol. 2016; no. 2016; pp. 1 - 12
Main Authors Mazzola, Salvatore, Colombo, Paolo, Cuttitta, Angela, Tagliavia, Marcello, Salamone, Monica, Bonura, Angela, Bennici, Carmelo, Vlah, Sara, Masullo, Tiziana, Longo, Alessandra, Bulati, Matteo, Nicosia, Aldo
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2016
John Wiley & Sons, Inc
Subjects
Anemonia viridis
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - isolation & purification
Apoptosis
Cancer
Cell Extracts - administration & dosage
Cell Extracts - isolation & purification
Cell growth
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Cells
Cytotoxicity
Dose-Response Relationship, Drug
Humans
Morphology
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - pathology
Peptides
Proteins
Sea Anemones - chemistry
Treatment Outcome
Tumors
Venom
Water quality
Italy
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Abstract In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone Anemonia viridis. Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis test, MTS, and LDH assays. Finally, the antiproliferative activities of three of these fractions were studied on PC3, PLC/PRF/5, and A375 human cancer cell lines. Our analysis revealed that the four fractions showed different protein contents and diverse patterns of activity towards human PBMC and cancer cell lines. Interestingly, fractions III and IV exerted cytotoxic effects on human cells. Conversely, fractions I and II displayed very low toxic effects associated with antiproliferative activities on cancer cell lines.
AbstractList In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone Anemonia viridis. Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis test, MTS, and LDH assays. Finally, the antiproliferative activities of three of these fractions were studied on PC3, PLC/PRF/5, and A375 human cancer cell lines. Our analysis revealed that the four fractions showed different protein contents and diverse patterns of activity towards human PBMC and cancer cell lines. Interestingly, fractions III and IV exerted cytotoxic effects on human cells. Conversely, fractions I and II displayed very low toxic effects associated with antiproliferative activities on cancer cell lines.In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone Anemonia viridis. Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis test, MTS, and LDH assays. Finally, the antiproliferative activities of three of these fractions were studied on PC3, PLC/PRF/5, and A375 human cancer cell lines. Our analysis revealed that the four fractions showed different protein contents and diverse patterns of activity towards human PBMC and cancer cell lines. Interestingly, fractions III and IV exerted cytotoxic effects on human cells. Conversely, fractions I and II displayed very low toxic effects associated with antiproliferative activities on cancer cell lines.
In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone Anemonia viridis. Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis test, MTS, and LDH assays. Finally, the antiproliferative activities of three of these fractions were studied on PC3, PLC/PRF/5, and A375 human cancer cell lines. Our analysis revealed that the four fractions showed different protein contents and diverse patterns of activity towards human PBMC and cancer cell lines. Interestingly, fractions III and IV exerted cytotoxic effects on human cells. Conversely, fractions I and II displayed very low toxic effects associated with antiproliferative activities on cancer cell lines.
In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone . Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis test, MTS, and LDH assays. Finally, the antiproliferative activities of three of these fractions were studied on PC3, PLC/PRF/5, and A375 human cancer cell lines. Our analysis revealed that the four fractions showed different protein contents and diverse patterns of activity towards human PBMC and cancer cell lines. Interestingly, fractions III and IV exerted cytotoxic effects on human cells. Conversely, fractions I and II displayed very low toxic effects associated with antiproliferative activities on cancer cell lines.
In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone Anemonia viridis . Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis test, MTS, and LDH assays. Finally, the antiproliferative activities of three of these fractions were studied on PC3, PLC/PRF/5, and A375 human cancer cell lines. Our analysis revealed that the four fractions showed different protein contents and diverse patterns of activity towards human PBMC and cancer cell lines. Interestingly, fractions III and IV exerted cytotoxic effects on human cells. Conversely, fractions I and II displayed very low toxic effects associated with antiproliferative activities on cancer cell lines.
Audience Academic
Author Bulati, Matteo
Colombo, Paolo
Nicosia, Aldo
Bennici, Carmelo
Cuttitta, Angela
Tagliavia, Marcello
Masullo, Tiziana
Bonura, Angela
Vlah, Sara
Salamone, Monica
Longo, Alessandra
Mazzola, Salvatore
AuthorAffiliation 2 Laboratory of Molecular Ecology and Biotechnology, National Research Council, Institute for Marine and Coastal Environment (IAMC-CNR), Detached Unit of Capo Granitola, Torretta Granitola, 91021 Trapani, Italy
1 Istituto di Biomedicina e di Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Via Ugo La Malfa 153, 90146 Palermo, Italy
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/27725939$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Copyright © 2016 Matteo Bulati et al.
COPYRIGHT 2016 John Wiley & Sons, Inc.
Copyright © 2016 Matteo Bulati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2016 Matteo Bulati et al. 2016
Copyright_xml – notice: Copyright © 2016 Matteo Bulati et al.
– notice: COPYRIGHT 2016 John Wiley & Sons, Inc.
– notice: Copyright © 2016 Matteo Bulati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2016 Matteo Bulati et al. 2016
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Snippet In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase...
SourceID pubmedcentral
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gale
pubmed
crossref
hindawi
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SourceType Open Access Repository
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StartPage 1
SubjectTerms Anemonia viridis
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - isolation & purification
Apoptosis
Cancer
Cell Extracts - administration & dosage
Cell Extracts - isolation & purification
Cell growth
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Cells
Cytotoxicity
Dose-Response Relationship, Drug
Humans
Morphology
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - pathology
Peptides
Proteins
Sea Anemones - chemistry
Treatment Outcome
Tumors
Venom
Water quality
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Title Partially Purified Extracts of Sea Anemone Anemonia viridis Affect the Growth and Viability of Selected Tumour Cell Lines
URI https://search.emarefa.net/detail/BIM-1097477
https://dx.doi.org/10.1155/2016/3849897
https://www.ncbi.nlm.nih.gov/pubmed/27725939
https://www.proquest.com/docview/1825206197
https://www.proquest.com/docview/1835386153
https://www.proquest.com/docview/1837328373
https://pubmed.ncbi.nlm.nih.gov/PMC5048049
Volume 2016
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