Molecular imaging with single-walled carbon nanotubes

• Published in: Nano today Vol. 4; no. 3; pp. 252 - 261
• Main Authors: Hong, Hao, Gao, Ting, Cai, Weibo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2009
• Subjects: Molecular imaging; Near-infrared fluorescence (NIRF); Photoacoustic tomography (PAT); Positron emission tomography (PET); Raman spectroscopy; Single-walled carbon nanotubes (SWCNTs); Single-walled carbon nanotubes (SWCNTs); Molecular imaging; Positron emission tomography (PET); Raman spectroscopy; Near-infrared fluorescence (NIRF); Photoacoustic tomography (PAT)
• ISSN: 1748-0132; 1878-044X
• DOI: 10.1016/j.nantod.2009.04.002

Nanoparticle-based molecular imaging has emerged as an interdisciplinary field which involves physics, chemistry, engineering, biology, and medicine. Single-walled carbon nanotubes (SWCNTs) have unique properties which make them suitable for applications in a variety of imaging modalities, such as magnetic resonance, near-infrared fluorescence, Raman spectroscopy, photoacoustic tomography, and radionuclide-based imaging. In this review, we will summarize the current state-of-the-art of SWCNTs in molecular imaging applications. Multifunctionality is the key advantage of nanoparticles over traditional approaches. Targeting ligands, imaging labels, therapeutic drugs, and many other agents can all be integrated into the nanoparticle to allow for targeted molecular imaging and molecular therapy by encompassing many biological and biophysical barriers. A multifunctional, SWCNT-based nanoplatform holds great potential for clinical applications in the future.