Clinical Evidence for the Use of Octenidine Dihydrochloride to Prevent Healthcare-Associated Infections and Decrease Staphylococcus aureus Carriage or Transmission-A Review

• Published in: Pathogens (Basel) Vol. 12; no. 4; p. 612
• Main Authors: Köck, Robin, Denkel, Luisa, Feßler, Andrea T, Eicker, Rudolf, Mellmann, Alexander, Schwarz, Stefan, Geffers, Christine, Hübner, Nils-Olaf, Leistner, Rasmus
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.04.2023; MDPI
• Subjects: Antibiotics; Antiseptics; Bacteria; Bathing; blood cultures; Catheters; Decolonization; decontamination; Disinfection & disinfectants; Gram-negative bacteria; Gram-positive bacteria; Infectious diseases; Medical instruments; Microorganisms; MRSA; nosocomial; Nosocomial infection; Nosocomial infections; Orthopedics; postoperative; Prevention; Review; Reviews; Skin; Skin preparations; Staphylococcus aureus; Staphylococcus infections; Success; Surgery; Surgical site infections; wound infection; postoperative; CLABSI; decontamination; wound infection; nosocomial; blood cultures; eradication; MRSA
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens12040612

The antiseptic agent octenidine dihydrochloride (OCT) is used for skin preparation, for decolonization, and within bundles for the prevention of catheter-related or surgical site infections (SSIs). Here, we review the evidence for the effects of OCT from clinical studies. Review of studies published in the Medline, Scopus, and Cochrane databases until August 2022, performed in clinical settings and reporting on effects of OCT on carriage/transmission, SSI prevention, and prevention of intensive care unit (ICU)-related or catheter-related bloodstream and insertion site infections. We included 31 articles. The success of decolonization with OCT-containing therapies ranged between 6 and 87%. Single studies demonstrated that OCT application led to a reduction in infections, acquisition, and carriage. No study compared OCT for skin preparation before surgical interventions to other antiseptics. Weak evidence for the use of OCT for pre-operative washing was found in orthopedic and cardiac surgery, if combined with other topical measures. Mostly, studies did not demonstrate that daily OCT bathing reduced ICU-/catheter-related bloodstream infections with one exception. There is a need to perform studies assessing the clinical use of OCT compared with other antiseptics with respect to its effectiveness to prevent nosocomial infections.