EASL Clinical Practice Guidelines: Drug-induced liver injury

Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver disorders faced by hepatologists, because of the myriad of drugs used in clinical practice, available herbs and dietary supplements with hepatotoxic potential, the ability of the condition to present with a...

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Bibliographic Details
Published inJournal of hepatology Vol. 70; no. 6; pp. 1222 - 1261
Main Authors Andrade, Raúl J., Aithal, Guruprasad P., Björnsson, Einar S., Kaplowitz, Neil, Kullak-Ublick, Gerd A., Larrey, Dominique, Karlsen, Tom H.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2019
Elsevier Science Ltd
Subjects
Clinical medicine
Clinical practice guidelines
Diagnosis
Dietary supplements
Hepatotoxicity
Liver
Liver diseases
Phenotypes
Risk factors
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Summary:Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver disorders faced by hepatologists, because of the myriad of drugs used in clinical practice, available herbs and dietary supplements with hepatotoxic potential, the ability of the condition to present with a variety of clinical and pathological phenotypes and the current absence of specific biomarkers. This makes the diagnosis of drug-induced liver injury an uncertain process, requiring a high degree of awareness of the condition and the careful exclusion of alternative aetiologies of liver disease. Idiosyncratic hepatotoxicity can be severe, leading to a particularly serious variety of acute liver failure for which no effective therapy has yet been developed. These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2019.02.014