Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

• Published in: Annals of the New York Academy of Sciences Vol. 1300; no. 1; pp. 187 - 199
• Main Authors: Fang, Yu, Chen, Xiaoxin, Bajpai, Manisha, Verma, Amit, Das, Kiron M., Souza, Rhonda F., Garman, Katherine S., Donohoe, Claire L., O'Farrell, Naoimh J., Reynolds, John V., Dvorak, Katerina
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2013; Wiley Subscription Services, Inc
• Subjects: Activation; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Animals; autophagy; Barrett Esophagus - genetics; Barrett Esophagus - metabolism; Barrett Esophagus - pathology; Barrett's esophagus; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Boundary element method; Cancer; Carcinogens; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Cellular; Disease Models, Animal; DNA Methylation; esophageal adenocarcinoma; Esophageal cancer; Esophageal Neoplasms - genetics; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - pathology; Esophagus; Health risk assessment; Humans; Instability; Mathematical analysis; obesity; DNA methylation; autophagy; esophageal adenocarcinoma; obesity; Barrett's esophagus
• ISSN: 0077-8923; 1749-6632
• DOI: 10.1111/nyas.12249

This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid‐ and bile‐induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome‐wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell‐death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.