Pathophysiological changes associated with dietary melamine and cyanuric acid toxicity in red tilapia
This study examined the adverse effects of feed‐delivered melamine (MEL) and cyanuric acid (CYA) in red tilapia. Diet 1 (without MEL and CYA), diets 2–4 (with MEL and CYA at 2.5, 5 and 7.5 g kg−1 diet, respectively) and diets 5 and 6 (with either MEL or CYA at 10 g kg−1 diet) were examined. MEL alon...
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Published in | Journal of fish diseases Vol. 38; no. 2; pp. 161 - 173 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.02.2015
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Subjects | |
Online Access | Get full text |
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Summary: | This study examined the adverse effects of feed‐delivered melamine (MEL) and cyanuric acid (CYA) in red tilapia. Diet 1 (without MEL and CYA), diets 2–4 (with MEL and CYA at 2.5, 5 and 7.5 g kg−1 diet, respectively) and diets 5 and 6 (with either MEL or CYA at 10 g kg−1 diet) were examined. MEL alone lowered both growth and FCR (P < 0.05), and CYA alone reduced the FCR of tilapia. Protein efficiency ratio and apparent net utilization of fish on diets 2–6 were poor (P < 0.05). The renal tubules of fish ingested MEL‐CYA combination had melamine–cyanurate crystals. On the other hand, diets with only one chemical did not induce such crystals. MEL and CYA in whole body, fillet or viscera reflected their dietary inclusion levels. The levels of Hsp70 were increased in the liver of fish that ingested MEL and CYA, in combination or singly (P < 0.05). However, in the kidney, such an increase was visible only in the fish that received diet 4 (P < 0.05). Combination of MEL and CYA at inclusion levels > 5 g kg−1 diet induced the activity of catalase in liver and the activity of glutathione peroxidase in liver and kidneys. Therefore, these adulterants should not be included in fish feeds. |
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Bibliography: | Office of the Higher Education Commission - No. NAT540528S ArticleID:JFD12219 Higher Education Research Promotion and National Research University Project of Thailand Center of Excellence on Agricultural Biotechnology - No. AG-BIO/PERDO-CHE ark:/67375/WNG-GTHQR8PX-H istex:B746F0FCFB50FD90906AFED699DEED46F0681F45 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0140-7775 1365-2761 |
DOI: | 10.1111/jfd.12219 |