Cyclisation Reactions Involving Alkyl Enol Ethers

Enol ethers are a fascinating product class and valuable building blocks with versatile reactivities and synthetic applications. With the emergence of silyl enol ethers, the chemistry of simple alkyl enol ethers has received less attention and targeted reviews of their chemistry are scarce. Especial...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 361; no. 23; pp. 5284 - 5304
Main Authors Lempenauer, Luisa, Lemière, Gilles, Duñach, Elisabet
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 03.12.2019
Wiley-VCH Verlag
Subjects
catalysis
Chemical Sciences
Chemists
cyclisations
enol ethers
Ethers
intramolecular reactions
Lewis acids
Organic chemistry
Substrates
Lewis acid
catalysis
cyclisations
intramolecular reactions
enol ethers
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Summary:Enol ethers are a fascinating product class and valuable building blocks with versatile reactivities and synthetic applications. With the emergence of silyl enol ethers, the chemistry of simple alkyl enol ethers has received less attention and targeted reviews of their chemistry are scarce. Especially intramolecular reactions under participation of an enol ether function have never been specifically surveyed. The construction of cyclic scaffolds is arguably one of the most important and challenging tasks of the organic chemist and intramolecular cyclisations represent the most straight‐forward tool to achieve this goal. The potential of enol ether‐containing substrates to form oxygenated carbo‐ and heterocycles is obvious. The purpose of this review is to discuss their particular reactivity and to direct the reader's attention to how their unique properties have been harnessed by organic chemists for the construction of rings.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201900478