Changes in maternal secretory immunoglobulin a levels in human milk during 12 weeks after parturition
Background Immune factors in human milk change in concentration after delivery. However, this concentration change during the early postpartum period has not yet been investigated in detail. Methods We measured Secretory IgA (SIgA) levels in the human milk of 91 postpartum mothers (after vaginal del...
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Published in | American journal of human biology Vol. 25; no. 3; pp. 399 - 403 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.05.2013
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Immune factors in human milk change in concentration after delivery. However, this concentration change during the early postpartum period has not yet been investigated in detail.
Methods
We measured Secretory IgA (SIgA) levels in the human milk of 91 postpartum mothers (after vaginal delivery) by using an enzyme immunoassay, in postpartum day 3, and weeks 1, 2, 3, 4, 8, and 12.
Results
The SIgA concentration gradually declined over the 12‐week period, with the highest level recorded in day 3. At week 4, the SIgA levels decreased to half the initial levels. Although the difference in concentration from one week to the next was remarkable, the decrease in concentration was rapid in the first 4 weeks but gradual from week 4 to week 12.
Conclusions
The SIgA levels gradually decreased up to week 12. However, the concentration of SIgA in breast milk did not change constantly. It changed relatively rapid until 4 weeks after childbirth, and because the concentration from the third day to the eighth week became 50%, it was understood that the change was temporal. Am. J. Hum. Biol. 25:399–403, 2013. © 2013 Wiley Periodicals, Inc. |
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Bibliography: | istex:99CFA249F31762CF4E52BE6DE686E62A0E7061E0 ark:/67375/WNG-MF0PX7K5-J ArticleID:AJHB22387 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 1042-0533 1520-6300 |
DOI: | 10.1002/ajhb.22387 |