Cocaine-specific neuroplasticity in the ventral striatum network is linked to delay discounting and drug relapse

• Published in: Addiction (Abingdon, England) Vol. 110; no. 12; pp. 1953 - 1962
• Main Authors: Contreras-Rodríguez, Oren, Albein-Urios, Natalia, Perales, José C., Martínez-Gonzalez, José M., Vilar-López, Raquel, Fernández-Serrano, María J., Lozano-Rojas, Oscar, Verdejo-García, Antonio
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.12.2015
• Subjects: Adult; Age of Onset; Cocaine; Cocaine - adverse effects; Cocaine-Related Disorders - physiopathology; Cocaine-Related Disorders - psychology; compulsivity; Delay Discounting - drug effects; Dopamine Uptake Inhibitors - adverse effects; Epidemiologic Methods; Female; Gambling; Gambling - physiopathology; Humans; Impulsive Behavior - drug effects; Impulsivity; Magnetic Resonance Imaging; Male; Neural Pathways - drug effects; Neuronal Plasticity - drug effects; Neuropsychology; Recurrence; relapse; striatum; Substance abuse treatment; Ventral Striatum - drug effects; gambling; impulsivity; Cocaine; striatum; compulsivity; relapse
• ISSN: 0965-2140; 1360-0443
• DOI: 10.1111/add.13076

Aims To contrast functional connectivity on ventral and dorsal striatum networks in cocaine dependence relative to pathological gambling, via a resting‐state functional connectivity approach; and to determine the association between cocaine dependence‐related neuroadaptations indexed by functional connectivity and impulsivity, compulsivity and drug relapse. Design Cross‐sectional study of 20 individuals with cocaine dependence (CD), 19 individuals with pathological gambling (PG) and 21 healthy controls (HC), and a prospective cohort study of 20 CD followed‐up for 12 weeks to measure drug relapse. Setting and Participants CD and PG were recruited through consecutive admissions to a public clinic specialized in substance addiction treatment (Centro Provincial de Drogodependencias) and a public clinic specialized in gambling treatment (AGRAJER), respectively; HC were recruited through community advertisement in the same area in Granada (Spain). Measurements Seed‐based functional connectivity in the ventral striatum (ventral caudate and ventral putamen) and dorsal striatum (dorsal caudate and dorsal putamen), the Kirby delay‐discounting questionnaire, the reversal‐learning task and a dichotomous measure of cocaine relapse indicated with self‐report and urine tests. Findings CD relative to PG exhibit enhanced connectivity between the ventral caudate seed and subgenual anterior cingulate cortex, the ventral putamen seed and dorsomedial pre‐frontal cortex and the dorsal putamen seed and insula (P ≤ 0.001, kE = 108). Connectivity between the ventral caudate seed and subgenual anterior cingulate cortex is associated with steeper delay discounting (P ≤ 0.001, kE = 108) and cocaine relapse (P ≤ 0.005, kE = 34). Conclusions Cocaine dependence‐related neuroadaptations in the ventral striatum of the brain network are associated with increased impulsivity and higher rate of cocaine relapse.