Isolation and Structure of Two Metabolites of a Macrolide Antibiotic, SF-837 Substance

• Published in: Chemical & pharmaceutical bulletin Vol. 20; no. 11; pp. 2366 - 2371
• Main Authors: INOUYE, SHIGEHARU, SHOMURA, TOMOKO, TSURUOKA, TAKASHI, OMOTO, SHOJI, NIIDA, TARO, UMEMURA, KOSHIRO
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 1972; Japan Science and Technology Agency
• Subjects: Animals; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - urine; Bile - metabolism; Glycosides - metabolism; Lactones - metabolism; Liver - metabolism; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Rats

M1 Substance, one of the main metabolites of SF-837, was isolated from the urine of rats, or digested solution of SF-837 with a liver homogenate, and identified as 4"-depropionyl SF-837 by direct comparison. Another major metabolite, M2 substance was isolated from the bile of rats, and its stru...